Division for Health Service Promotion, The University of Tokyo, Tokyo 113-0033, Japan.
Department of Oral & Maxillofacial Surgery, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
Int J Environ Res Public Health. 2020 Jun 16;17(12):4290. doi: 10.3390/ijerph17124290.
Though it is well known that periodontal diseases are associated with various systemic diseases in adults, the associations in late adolescents have not been adequately elucidated. We investigated the association between gum bleeding (a major symptom of periodontal diseases) and common systemic diseases in late adolescents: allergic, respiratory, and otorhinolaryngologic diseases.
We conducted a retrospective review of the mandatory medical questionnaires administered as a part of legally required freshman medical checkup between April 2017 and April 2019 at the University of Tokyo. Among the total of 9376 sets of responses, 9098 sets from students aged less than 20 were analyzed. An χ2 test and univariate and multivariate binomial logistic regression analyses were performed using SAS ver. 9.4. A value of < 0.05 was accepted as significant.
According to the questionnaire data, 3321 students (36.5%; 2780 males and 541 females) responded that they experienced gum bleeding whenever they brushed their teeth. These students had significantly higher incidence rates of otitis media/externa and asthma/cough-variant asthma ( = 0.001 and = 0.006, respectively). The results of the multivariate analysis showed significant rates of the following complications among these students: (1) otitis media/externa (odds ratio (OR) 1.691; 95% confidence interval (CI): 1.193-2.396; = 0.003), (2) asthma/cough-variant asthma (OR 1.303; 95% CI: 1.091-1.556; = 0.003), and (3) male gender (OR 1.536; 95% CI: 1.337-1.765; < 0.001).
Gum bleeding was closely associated with otitis media/externa and asthma in late adolescents. Our study reinforces new evidence about the association between periodontal diseases and asthma, and it reveals a novel and close association between gum bleeding and otitis media/externa.
尽管牙周病与成年人的各种系统性疾病有关已广为人知，但青少年晚期的关联尚未得到充分阐明。我们研究了牙龈出血（牙周病的主要症状）与青少年晚期常见的全身疾病：过敏、呼吸和耳鼻喉疾病之间的关系。
我们对 2017 年 4 月至 2019 年 4 月在东京大学作为法定新生体检强制性医学问卷的一部分进行了回顾性审查。在总共 9376 套答复中，分析了 9098 套来自年龄小于 20 岁的学生的答复。使用 SAS 版本 9.4 进行卡方检验和单变量和多变量二项逻辑回归分析。接受 < 0.05 的值作为显著。
根据问卷数据，3321 名学生（36.5%；2780 名男性和 541 名女性）表示，他们在刷牙时经常会出现牙龈出血。这些学生患有中耳炎/外耳炎和哮喘/咳嗽变异性哮喘的发生率明显更高（分别为 = 0.001 和 = 0.006）。多变量分析的结果表明，这些学生中存在以下并发症的发生率显著增加：（1）中耳炎/外耳炎（比值比（OR）1.691；95%置信区间（CI）：1.193-2.396； = 0.003），（2）哮喘/咳嗽变异性哮喘（OR 1.303；95%CI：1.091-1.556； = 0.003），和（3）男性（OR 1.536；95%CI：1.337-1.765； < 0.001）。
牙龈出血与青少年晚期的中耳炎/外耳炎和哮喘密切相关。我们的研究加强了牙周病与哮喘之间关联的新证据，并揭示了牙龈出血与中耳炎/外耳炎之间的新的密切关联。
