Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK.
Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK; Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt.
Drug Discov Today. 2020 Aug;25(8):1513-1520. doi: 10.1016/j.drudis.2020.06.006. Epub 2020 Jun 16.
Recently, remarkable efforts have focused on research towards enhancing and delivering efficacious and advanced therapeutic agents. Even though this involves significant challenges, innovative techniques and materials have been explored to overcome these. The advantageous properties of mesoporous silica nanoparticles (MSNs), such as unique morphologies and geometries, makes then favorable for use for various drug delivery targeting purposes, particularly in cancer therapy. As we discuss here, MSNs have been utilized over the past few decades to improve the efficiency of anticancer drugs by enhancing their solubility to render them suitable for application, reducing adverse effects, and improving their anticancer cytotoxic efficiency.
最近，人们致力于研究如何增强和输送有效且先进的治疗剂。尽管这面临着巨大的挑战，但人们已经探索出了创新的技术和材料来克服这些问题。介孔硅纳米粒子（MSNs）具有独特的形态和几何形状等优势特性，非常适合用于各种药物输送靶向治疗，特别是在癌症治疗方面。正如我们在这里讨论的那样，MSNs 在过去几十年中被用于提高抗癌药物的效率，通过提高其溶解度使它们更适合应用，减少不良反应，并提高其抗癌细胞毒性效率。
