Program in Craniofacial Biology, University of California San Francisco, San Francisco, CA, USA; Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, USA; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA.
School of Dentistry, University of California Los Angeles, Los Angeles, CA, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA.
Curr Opin Cell Biol. 2020 Oct;66:59-68. doi: 10.1016/j.ceb.2020.05.004. Epub 2020 Jun 20.
Morphogenesis is a physical process that requires the generation of mechanical forces to achieve dynamic changes in cell position, tissue shape, and size as well as biochemical signals to coordinate these events. Mechanical forces are also used by the embryo to transmit detailed information across space and detected by target cells, leading to downstream changes in cellular properties and behaviors. Indeed, forces provide signaling information of complementary quality that can both synergize and diversify the functional outputs of biochemical signaling. Here, we discuss recent findings that reveal how mechanical signaling and biochemical signaling are integrated during morphogenesis and the possible context-specific advantages conferred by the interactions between these signaling mechanisms.
形态发生是一个物理过程，需要产生机械力来实现细胞位置、组织形状和大小的动态变化，以及协调这些事件的生化信号。胚胎也利用机械力在空间中传递详细信息，并被靶细胞检测到，从而导致细胞特性和行为的下游变化。事实上，力提供了互补质量的信号信息，既可以协同又可以多样化生化信号的功能输出。在这里，我们讨论了最近的发现，这些发现揭示了在形态发生过程中机械信号和生化信号是如何整合的，以及这些信号机制之间的相互作用赋予的可能特定于上下文的优势。
