Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands.
Donders Institute for Brain, Cognition and Behavior, Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.
Sci Rep. 2020 Jun 24;10(1):10235. doi: 10.1038/s41598-020-66404-z.
Entry to center-based childcare (CC) at three months of life can be an important challenge for infants as it includes major stressors such as long maternal separations and frequently changing caregivers. Stress and the new environment may in turn alter the composition of the gut microbiota with possible implications for future health outcomes. As part of an ongoing longitudinal study, we investigated whether CC, as compared to being cared for by the parents at home, alters the composition of the gut microbiota, while accounting for known covariates of the infant gut microbiota. Stool samples of infants who entered CC (n = 49) and control infants (n = 49) were obtained before and four weeks after CC entrance. Using Redundancy analysis, Random Forests and Bayesian linear models we found that infant gut microbiota was not affected in a uniform way by entry to CC. In line with the literature, breastfeeding, birth mode, age, and the presence of siblings were shown to significantly impact the microbial composition.
婴儿在三个月大时进入日托中心（CC）可能是一个重要的挑战，因为这包括主要的压力源，如长时间与母亲分离和频繁更换照顾者。压力和新环境反过来可能会改变肠道微生物群的组成，这可能对未来的健康结果产生影响。作为一项正在进行的纵向研究的一部分，我们调查了 CC 是否会改变肠道微生物群的组成，同时考虑到婴儿肠道微生物群的已知协变量，与由父母在家照顾相比。在 CC 进入（n = 49）和对照组婴儿（n = 49）之前和进入 CC 四周后收集了粪便样本。使用冗余分析、随机森林和贝叶斯线性模型，我们发现婴儿肠道微生物群不受 CC 进入的统一影响。与文献一致的是，母乳喂养、分娩方式、年龄和兄弟姐妹的存在被证明会显著影响微生物组成。
