Todorovic Nikola, Zanini Dragana, Stajer Valdemar, Korovljev Darinka, Ostojic Jelena, Ostojic Sergej M
Applied Bioenergetics Lab Faculty of Sport and PE University of Novi Sad Novi Sad Serbia.
Faculty of Health Sciences University of Pecs Pecs Hungary.
Food Sci Nutr. 2021 Jul 19;9(9):5139-5145. doi: 10.1002/fsn3.2480. eCollection 2021 Sep.
The main aim of this randomized-controlled cross-over interventional trial was to assess the acute effects of taking a single dose of hydrogen-rich water (HRW), and compare it with caffeine, HRW plus caffeine, and control water, for alertness, brain metabolism, brain and oxygen saturation, and self-reported adverse events in healthy men and women who were habitual coffee drinkers and were sleep-deprived for 24 hr. Sixteen apparently healthy young adults (8 men and 8 women; age 24.0 ± 3.5 years) were allocated in a cross-over design to receive a single-dose drink of HRW (8 ppm), caffeine (50 mg), HRW plus caffeine, or control drink (tap water) in the morning after 24-hr sleep deprivation and 12-hr fasting. The primary and secondary outcomes were assessed at baseline (pre-intervention) and 15-min follow-up. Significantly less time was needed to complete trail-making test after both HRW and HRW plus caffeine compared with the control drink ( < .05). The number of errors in the symbol digit modalities test was significantly lower after drinking HRW or caffeine than control drink ( < .05). Both HRW and caffeine significantly increased the choline-to-creatine ratio in several brain regions (frontal white and gray matter), while HRW and the combination intervention also affected brain metabolism in the paracentral brain. No participants reported any side effects from any intervention. The attention enhancement driven by HRW appears along with changes in brain metabolism. Being generally recognized as a safe intervention, hydrogen could be thus recommended as a novel intervention that upholds attention in stressed conditions, with its metabolic footprint likely different from caffeine.
这项随机对照交叉干预试验的主要目的是评估单剂量饮用富氢水（HRW）的急性效应，并将其与咖啡因、HRW加咖啡因以及对照水进行比较，以观察其对习惯喝咖啡且被剥夺24小时睡眠的健康男性和女性的警觉性、脑代谢、脑血氧饱和度及自我报告的不良事件的影响。16名表面健康的年轻人（8名男性和8名女性；年龄24.0±3.5岁）采用交叉设计，在被剥夺24小时睡眠并禁食12小时后的早晨，分别接受单剂量的HRW（8ppm）、咖啡因（50毫克）、HRW加咖啡因或对照饮品（自来水）。在基线（干预前）和15分钟随访时评估主要和次要结局。与对照饮品相比，饮用HRW和HRW加咖啡因后完成连线测验所需的时间显著缩短（P<0.05）。饮用HRW或咖啡因后，符号数字模式测验中的错误数量显著低于对照饮品（P<0.05）。HRW和咖啡因均显著提高了几个脑区（额叶白质和灰质）的胆碱与肌酸比值，而HRW及联合干预也影响了中央旁脑区的脑代谢。没有参与者报告任何干预措施产生的副作用。HRW引起的注意力增强似乎与脑代谢变化同时出现。由于氢通常被认为是一种安全的干预措施，因此可以推荐其作为一种在压力条件下维持注意力的新型干预措施，其代谢足迹可能与咖啡因不同。
