Boire G, Ménard H A
Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke, PQ, Canada.
J Rheumatol. 1988 Mar;15(3):391-4.
A group of 12 patients with rheumatoid arthritis (RA) with anti-Ro antibody were compared to an age and sex matched group with RA. Both had similar articular manifestations but the anti-Ro positive patients had more severe extraarticular as well as serological abnormalities. Vasculitis, liver abnormalities, neutropenia and circulating immune complexes were prominent while sicca features were not. Treatment with remission inducing drugs failed frequently without increased toxicity. Two patients with classical RA with anti-Ro developed subacute cutaneous lupus erythematosus and anti-dsDNA. Our observations suggest that the presence of anti-Ro in RA sera may be a marker for a small but significant subset of rheumatoid disease.
将12名患有类风湿关节炎（RA）且抗Ro抗体呈阳性的患者与一组年龄和性别匹配的类风湿关节炎患者进行比较。两组患者的关节表现相似，但抗Ro阳性患者的关节外及血清学异常更为严重。血管炎、肝脏异常、中性粒细胞减少和循环免疫复合物较为突出，而干燥症状不明显。使用诱导缓解药物治疗常常失败，且未增加毒性。两名患有经典类风湿关节炎且抗Ro抗体呈阳性的患者出现了亚急性皮肤型红斑狼疮和抗双链DNA抗体。我们的观察结果表明，类风湿关节炎血清中抗Ro抗体的存在可能是一小部分但具有重要意义的类风湿疾病亚组的标志物。
