Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Ren Fail. 2020 Nov;42(1):600-606. doi: 10.1080/0886022X.2020.1783680.
Serum C-reactive protein to albumin ratio (CAR) was recently identified as a poor marker of prognosis among various populations. The current study aimed to examine the association between CAR and all-cause mortality among patients undergoing peritoneal dialysis (PD). A total of 758 patients with PD were included in this study during the period from 1 November 2005 to 28 February 2017 and followed up until 31 May 2017. The primary outcome was all-cause mortality. We used multivariate Cox proportional hazard models and Kaplan-Meier survival curves to assess the relationship between CAR and all-cause mortality in these patients. Among 758 participants, mean age was 49.1 ± 14.2 years, with 56% males and 18.6% prevalence of diabetes. Median CAR was 0.13 (interquartile range [IQR], 0.07-0.34). After 27 months (IQR, 14-40 months) of follow-up, 157 deaths had been reported. After adjusting for confounding factors, we found a significant association between serum CAR and all-cause mortality among those in the highest CAR group (hazard ratio 1.91, 95% confidence interval 1.05- 3.47, = 0.034). In patients undergoing PD, an increase in serum CAR is independently associated with increased risk for all-cause mortality.
血清 C 反应蛋白与白蛋白比值（CAR）最近被确定为各种人群预后不良的标志物。本研究旨在探讨腹膜透析（PD）患者中 CAR 与全因死亡率之间的关系。这项研究共纳入了 2005 年 11 月 1 日至 2017 年 2 月 28 日期间的 758 名 PD 患者，并随访至 2017 年 5 月 31 日。主要结局是全因死亡率。我们使用多变量 Cox 比例风险模型和 Kaplan-Meier 生存曲线评估了 CAR 与这些患者全因死亡率之间的关系。在 758 名参与者中，平均年龄为 49.1±14.2 岁，男性占 56%，糖尿病患病率为 18.6%。CAR 的中位数为 0.13（四分位距 [IQR]，0.07-0.34）。在 27 个月（IQR，14-40 个月）的随访后，报告了 157 例死亡。在调整了混杂因素后，我们发现 CAR 最高组的血清 CAR 与全因死亡率之间存在显著相关性（危险比 1.91，95%置信区间 1.05-3.47，P=0.034）。在接受 PD 治疗的患者中，血清 CAR 的增加与全因死亡率的增加独立相关。
