Lutzweiler Gaëtan, Ndreu Halili Albana, Engin Vrana Nihal
Institut National de la Santé et de la Recherche Medicale, UMR_S 1121, 11 rue Humann, 67085 Strasbourg CEDEX, France.
Department of Information Technology, Aleksander Moisiu University, 2001 Durres, Albania.
Pharmaceutics. 2020 Jun 29;12(7):602. doi: 10.3390/pharmaceutics12070602.
Porous scaffolds have been employed for decades in the biomedical field where researchers have been seeking to produce an environment which could approach one of the extracellular matrixes supporting cells in natural tissues. Such three-dimensional systems offer many degrees of freedom to modulate cell activity, ranging from the chemistry of the structure and the architectural properties such as the porosity, the pore, and interconnection size. All these features can be exploited synergistically to tailor the cell-material interactions, and further, the tissue growth within the voids of the scaffold. Herein, an overview of the materials employed to generate porous scaffolds as well as the various techniques that are used to process them is supplied. Furthermore, scaffold parameters which modulate cell behavior are identified under distinct aspects: the architecture of inert scaffolds (i.e., pore and interconnection size, porosity, mechanical properties, etc.) alone on cell functions followed by comparison with bioactive scaffolds to grasp the most relevant features driving tissue regeneration. Finally, outcomes are highlighted comparing the accordance between and results in order to tackle the future translational challenges in tissue repair and regeneration.
几十年来，多孔支架一直在生物医学领域得到应用，在该领域中，研究人员一直在寻求创造一种环境，使其能够接近支持天然组织中细胞的细胞外基质之一。这种三维系统为调节细胞活性提供了多种自由度，范围涵盖结构的化学性质以及诸如孔隙率、孔径和互连尺寸等结构特性。所有这些特征都可以协同利用，以调整细胞与材料之间的相互作用，进而调控支架孔隙内的组织生长。本文提供了用于制备多孔支架的材料概述以及用于加工这些材料的各种技术。此外，从不同方面确定了调节细胞行为的支架参数：仅惰性支架的结构（即孔径和互连尺寸、孔隙率、力学性能等）对细胞功能的影响，随后与生物活性支架进行比较，以掌握驱动组织再生的最相关特征。最后，突出比较了[此处原文缺失相关内容]和[此处原文缺失相关内容]结果之间的一致性，以便应对组织修复和再生领域未来的转化挑战。
