Therapeutic Process Department, Faculty of Health, Universidad Católica de Temuco, Temuco, Chile.
Kinesiology Department, Faculty of Health Sciences, Universidad Católica del Maule, Talca, Chile.
Exp Gerontol. 2020 Sep;138:111012. doi: 10.1016/j.exger.2020.111012. Epub 2020 Jun 30.
Resistance exercise training (RET) has proven effective at reducing the risk of chronic disease in older populations, and it appears to regulate redox homeostasis.
To determine the effects of RET on redox homeostasis in older people.
A systematic review and meta-analysis of randomized clinical trials identified by searching MEDLINE, Web of Science, EMBASE, Sportdiscus, LILACS, CENTRAL and CINAHL. We included studies of subjects aged 65 years or older, with or without pathologies, and including RET metrics with quantified molecular oxidation and antioxidant capacity outcomes.
Fifteen studies were included in this review. Agreement between reviewers reached a kappa value of 0.725. There were a total of 614 participants, with an average age of 68.1 years. Five (for molecular oxidation markers) and three (for antioxidant capacity markers) studies included data that quantified the effects of RET on homeostasis redox. The results of the meta-analysis showed that there were no differences in the molecular oxidation markers (SMD = -0.26; 95% CI = -0.57 to 0.05; P = 0.10; I2 = 0%) and antioxidant capacity markers (SMD = 0.53; 95% CI = -0.20 to 1.26; P = 0.16; I2 = 71.5%) in healthy older people after a RET of 8-24 weeks compared to non-intervention.
Based on a small number of studies of low methodological quality, this systematic review with meta-analysis suggests that RET is not effective at reducing molecular oxidation markers in healthy older people. More research is needed on the effects of RET on redox homeostasis in older people.
CRD42019121529.
阻力训练（RET）已被证明可有效降低老年人群慢性病的风险，并且似乎可以调节氧化还原稳态。
确定 RET 对老年人氧化还原稳态的影响。
通过搜索 MEDLINE、Web of Science、EMBASE、Sportdiscus、LILACS、CENTRAL 和 CINAHL，对已确定的随机临床试验进行系统评价和荟萃分析。我们纳入了年龄在 65 岁或以上、有或没有病理的受试者的研究，并纳入了具有量化分子氧化和抗氧化能力结果的 RET 指标。
本综述共纳入 15 项研究。两位审稿人之间的一致性达到了 0.725 的kappa 值。共有 614 名参与者，平均年龄为 68.1 岁。五项（针对分子氧化标志物）和三项（针对抗氧化能力标志物）研究纳入了量化 RET 对氧化还原稳态影响的数据。荟萃分析结果表明，在健康老年人中，RET 8-24 周后，分子氧化标志物（SMD=-0.26；95%CI=-0.57 至 0.05；P=0.10；I2=0%）和抗氧化能力标志物（SMD=0.53；95%CI=-0.20 至 1.26；P=0.16；I2=71.5%）无差异与非干预组相比。
基于少数低方法学质量的研究，本系统评价和荟萃分析表明，RET 不能有效降低健康老年人的分子氧化标志物。需要更多关于 RET 对老年人氧化还原稳态影响的研究。
PROSPERO 注册号：CRD42019121529。
