Microbiology and Immunology Laboratory, Federal University of Bahia, Anísio Teixeira Campus, Vitória da Conquista, Bahia, Brazil.
Santa Cruz State University, Ilhéus, Bahia, Brazil.
Epidemiol Infect. 2020 Jun 22;148:e126. doi: 10.1017/S0950268820001302.
Spontaneous abortion is considered a public health problem having several causes, including infections. Among the infectious agents, bacteria of the vaginal microbiota and Ureaplasma parvum have been associated with abortion, but their participation needs to be further elucidated. This study aims to evaluate the influence of Mollicutes on the development of spontaneous abortion. Women who underwent spontaneous abortion and those with normal birth (control) were studied. Samples of cervical mucus (CM) and placental tissue were collected to identify Mollicutes using the quantitative polymerase chain reaction methodology. Eighty-nine women who had a miscarriage and 20 women with normal pregnancies were studied. The presence of Mollicutes in placental tissue increased the chance of developing miscarriage sevenfold. The prevalence of U. parvum in women who experienced spontaneous abortion was 66.3% in placental tissue. A positive association was observed between the detection of U. parvum in samples of placental tissue and abortion. There was a significant increase in microbial load in placental tissue for M. hominis, U. urealyticum and U. parvum compared to the control group. Detection of U. parvum in CM in pregnant women can ascend to the region of the placental tissue and trigger a spontaneous abortion.
自然流产被认为是一个公共卫生问题，其原因有多种，包括感染。在感染因子中，阴道微生物群中的细菌和脲原体属细小脲原体与流产有关，但它们的参与需要进一步阐明。本研究旨在评估柔膜体纲对自然流产发展的影响。研究了自然流产的妇女和正常分娩的妇女（对照组）。采集宫颈粘液（CM）和胎盘组织样本，使用定量聚合酶链反应方法鉴定柔膜体纲。研究了 89 名流产妇女和 20 名正常妊娠妇女。胎盘组织中存在柔膜体纲会使流产的几率增加 7 倍。在经历自然流产的妇女中，胎盘组织中脲原体属细小脲原体的检出率为 66.3%。在胎盘组织中检测到脲原体属细小脲原体与流产呈正相关。与对照组相比，胎盘组织中 M. hominis、U. urealyticum 和 U. parvum 的微生物负荷显著增加。孕妇 CM 中 U. parvum 的检出可上升至胎盘组织区域，并引发自然流产。
