School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Södra Grev Rosengatan 32, 703 62 Örebro, Sweden.
Genetic Analysis AS, Kabelgata 8, 0580 Oslo, Norway.
Nutrients. 2020 Jun 30;12(7):1954. doi: 10.3390/nu12071954.
The effect of dietary fibres on intestinal barrier function has not been well studied, especially in the elderly. We aimed to investigate the potential of the dietary fibres oat β-glucan and wheat arabinoxylan to strengthen the intestinal barrier function and counteract acute non-steroid anti-inflammatory drug (indomethacin)-induced hyperpermeability in the elderly. A general population of elderly subjects (≥65 years, = 49) was randomised to a daily supplementation (12g/day) of oat β-glucan, arabinoxylan or placebo (maltodextrin) for six weeks. The primary outcome was change in acute indomethacin-induced intestinal permeability from baseline, assessed by an in vivo multi-sugar permeability test. Secondary outcomes were changes from baseline in: gut microbiota composition, systemic inflammatory status and self-reported health. Despite a majority of the study population (85%) showing a habitual fibre intake below the recommendation, no significant effects on acute indomethacin-induced intestinal hyperpermeability in vivo or gut microbiota composition were observed after six weeks intervention with either dietary fibre, compared to placebo.
膳食纤维对肠道屏障功能的影响尚未得到很好的研究，特别是在老年人中。我们旨在研究膳食纤维燕麦β-葡聚糖和小麦阿拉伯木聚糖增强肠道屏障功能和对抗老年人急性非甾体抗炎药（吲哚美辛）诱导的高通透性的潜力。将一般老年人群（≥65 岁，n=49）随机分为每天补充燕麦β-葡聚糖、阿拉伯木聚糖或安慰剂（麦芽糊精）12 克/天，持续 6 周。主要结局是通过体内多糖通透性试验评估急性吲哚美辛诱导的肠道通透性从基线的变化。次要结局是从基线开始的变化：肠道微生物群组成、全身炎症状态和自我报告的健康状况。尽管研究人群的大多数（85%）习惯性纤维摄入量低于推荐量，但与安慰剂相比，六周的膳食纤维干预后，对体内急性吲哚美辛诱导的肠道高通透性或肠道微生物群组成没有显著影响。
