新型冠状病毒肺炎家族聚集性病例的流行病学和临床特征。
Epidemiological and clinical characteristics of a familial cluster of COVID-19.
机构信息
Department of Endocrinology and Metabolism, Dazhou Central Hopsital, Dazhou, Sichuan, China.
Department of Intensive Care Unit, Dazhou Central Hospital, Dazhou, Sichuan, China.
出版信息
Epidemiol Infect. 2020 Jul 7;148:e145. doi: 10.1017/S0950268820001521.
Abstract
We report a family cluster of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection involving five patients in a family cluster in Dazhou, China, including the epidemiological, clinical, laboratory and radiological findings. Three-generation transmission was observed. Through epidemiological investigation, we observed asymptomatic transmission to a cohabiting family member, as well as person-to-person transmission of SARS-CoV-2 outside Wuhan city. The asymptomatic transmission demonstrated here provides evidence that there could be a greater risk of Coronavirus Disease 2019 (COVID-19) spread. This cluster also demonstrated that COVID-19 is transmissible during the incubation period of an asymptomatic person. Early isolation and treatment, stressing prevention of cluster outbreaks, could help prevent further spread of the epidemic.
摘要
我们报告了一起发生在中国达州的严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染的家族聚集性病例，该家族中有 5 名患者，包括流行病学、临床、实验室和影像学结果。观察到了三代传播。通过流行病学调查，我们观察到无症状传播给了同住的家庭成员，以及在武汉以外城市人与人之间传播 SARS-CoV-2。这里显示的无症状传播提供了证据，表明 2019 年冠状病毒病 (COVID-19) 的传播可能存在更大的风险。该聚集性病例还表明，COVID-19 在无症状感染者的潜伏期内具有传染性。早期隔离和治疗，强调预防聚集性疫情，有助于防止疫情进一步蔓延。
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