Department of Orthopedic Surgery, Musculoskeletal Research Center, Chang Gung Memorial Hospital and Chang Gung University, 5, Fu-Hsin St. Kweish, 33302, Tao-Yuan, Taiwan.
World J Surg. 2020 Nov;44(11):3737-3742. doi: 10.1007/s00268-020-05675-z. Epub 2020 Jul 6.
Open pelvic fractures are caused by high-energy traumas and are accompanied by organ injuries. Despite improvements in pre-hospital care, the acute mortality rate following open pelvic fractures remains high. This study aimed to report experiences in managing open pelvic fractures, identify potential independent predictors that contribute to acute mortality in such patients, and generate a scoring formula to predict mortality rate.
Open pelvic fracture patients managed during a 42-month period were retrospectively studied. Logistic regression analysis was used to determine predictors of acute mortality. Using the Youden index, threshold values of predictors were selected. Significant predictors were weighted to create a scoring formula. The area under the curve (AUC) was tested in this specific group.
The incidence of open pelvic fractures in all pelvic fractures was 4.9% (37/772), and the overall mortality rate was 21.6% (8/37). All the successfully resuscitated patients entered the reconstruction stage survived and underwent the complete treatment course. Univariate and multivariate logistic regression analyses revealed that the revised trauma score (RTS) was the single independent predictor of acute mortality. A scoring formula was generated following the statistical analysis. The probability of mortality was 0% and 100% when the score was above and below -2, respectively. This model predicted mortality with an AUC of 0.948 (95% confidence interval 0.881-1.000, P < 0.01).
The RTS may be a potential predictor of acute mortality in open pelvic fracture patients. Further work would be required to validate the clinical efficacy of the generated scoring formula.
开放性骨盆骨折由高能创伤引起,并伴有器官损伤。尽管在院前护理方面有所改进,但开放性骨盆骨折后的急性死亡率仍然很高。本研究旨在报告处理开放性骨盆骨折的经验,确定导致此类患者急性死亡的潜在独立预测因素,并生成一个评分公式来预测死亡率。
回顾性研究了在 42 个月期间接受治疗的开放性骨盆骨折患者。使用逻辑回归分析确定急性死亡率的预测因素。使用约登指数选择预测因素的阈值值。对有意义的预测因素进行加权以创建评分公式。在该特定组中测试曲线下面积(AUC)。
所有骨盆骨折中开放性骨盆骨折的发生率为 4.9%(37/772),总死亡率为 21.6%(8/37)。所有成功复苏的患者均进入重建阶段并存活下来,并完成了完整的治疗过程。单因素和多因素逻辑回归分析表明,修订创伤评分(RTS)是急性死亡率的唯一独立预测因素。经过统计分析后生成了一个评分公式。评分高于-2 时,死亡率为 0%;评分低于-2 时,死亡率为 100%。该模型预测死亡率的 AUC 为 0.948(95%置信区间 0.881-1.000,P<0.01)。
RTS 可能是开放性骨盆骨折患者急性死亡率的潜在预测因素。需要进一步的工作来验证生成的评分公式的临床疗效。