School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA.
National Center for Pharmaceuticals, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology, Riyadh 12354, Saudi Arabia.
Exp Biol Med (Maywood). 2020 Sep;245(15):1319-1325. doi: 10.1177/1535370220941258. Epub 2020 Jul 8.
The use of traditional tobacco products is a known risk factor for the development of diseases including periodontal disease. To date, the potential oral health effects related to electronic nicotine delivery systems (ENDS) use is unknown. This study collected saliva from ENDS users and never tobacco users to examine differences in the oral cavity of inflammatory cytokines and metabolites. The identification and measurement of these ENDS-related changes provide insight into disease pathways potentially associated with ENDS use. The utilization of saliva samples collected from human participates enhances the application of the findings compared to the majority of studies using cell culture and animal models. In addition, these foundational findings can inform future studies to examining specific pathways identified, interventional approaches, and application of translatable biomarkers of ENDS use.
使用传统烟草制品是导致牙周病等疾病的已知危险因素。迄今为止，与电子尼古丁传送系统（ENDS）使用相关的潜在口腔健康影响尚不清楚。本研究收集了来自ENDS 用户和从不吸烟的人的唾液，以研究口腔中炎症细胞因子和代谢物的差异。识别和测量这些与ENDS 相关的变化，为可能与ENDS 使用相关的疾病途径提供了深入了解。与大多数使用细胞培养和动物模型的研究相比，利用从人体参与者收集的唾液样本可增强研究结果的应用。此外，这些基础发现可以为未来的研究提供信息，以检查特定的途径、干预方法以及可转化的 ENDS 使用生物标志物的应用。
