Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Department of Histology and Cell biology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Nat Prod Res. 2021 Dec;35(23):5166-5176. doi: 10.1080/14786419.2020.1789636. Epub 2020 Jul 9.
Given the lack of adequate research on () Dyer Ex Eichler, this study was conducted focusing on different biological activities and phytochemical investigation of for the first time. showed strong protective activity against DNA damage and potent activity against VERO cell line. It also presented antimicrobial and hepatoprotective activity. Phytochemical investigation of the leaves resulted in isolation of two new flavonoids, apigenin 7---d-glucopyranoside (15) and amentoflavone 7---l-rhamnopyranoside (16), in addition to fifteen known compounds: phytone (1), trans-phytol (2), -sitosterol (3), stigmasterol (4), oliveriflavone (5), 7,4',7″,4″'-tetramethylamentoflavone (6), 7,4',7''-trimethylamentoflavone (7), scaidopitysin (8), bilobetin (9), isoginkgetin (10), aromadendrin (11), sotusflavone (12), engeletin (14) and eriocitrin (17) for the first time together with amentoflavone (13). Compounds (11) and (13) displayed very strong cytotoxic activity and showed the highest protective activity against DNA damage.
鉴于对（）Dyer Ex Eichler 的研究不足，本研究首次聚焦于不同的生物活性和植物化学成分研究。结果表明，对 DNA 损伤具有很强的保护活性，对 VERO 细胞系具有很强的活性。它还具有抗菌和保肝活性。对叶子的植物化学成分研究导致分离出两种新的类黄酮，芹菜素 7---d-吡喃葡萄糖苷（15）和芹菜甲素 7---l-鼠李吡喃糖苷（16），以及十五种已知化合物：植物酮（1）、反式植醇（2）、β-谷甾醇（3）、豆甾醇（4）、橄榄黄素（5）、7,4',7″,4″'-四甲基芹菜甲素（6）、7,4',7''-三甲氧基芹菜甲素（7）、鲨烯二酮（8）、bilobetin（9）、异银杏黄素（10）、阿罗黄酮（11）、山奈黄素（12）、engelitin（14）和橙皮苷（17），这是首次将芹菜甲素（13）一起分离出来。化合物（11）和（13）表现出很强的细胞毒性活性，并显示出对 DNA 损伤最强的保护活性。
