Trevor Lucy V, Riches-Suman Kirsten, Mahajan Ajay L, Thornton M Julie
Plastic Surgery and Burns Research Unit, University of Bradford, Bradford BD71DP, UK.
Department of Plastic and Reconstructive Surgery, Bradford Teaching Hospitals NHS Foundation Trust, Bradford BD71DP, UK.
J Clin Med. 2020 Jul 8;9(7):2161. doi: 10.3390/jcm9072161.
Interest in adipose tissue is fast becoming a focus of research after many years of being considered as a simple connective tissue. It is becoming increasingly apparent that adipose tissue contains a number of diverse cell types, including adipose-derived stem cells (ASCs) with the potential to differentiate into a number of cell lineages, and thus has significant potential for developing therapies for regenerative medicine. Currently, there is no gold standard treatment for scars and impaired wound healing continues to be a challenge faced by clinicians worldwide. This review describes the current understanding of the origin, different types, anatomical location, and genetics of adipose tissue before discussing the properties of ASCs and their promising applications for tissue engineering, scarring, and wound healing.
在被视为简单结缔组织多年之后，对脂肪组织的研究兴趣正迅速成为一个研究焦点。越来越明显的是，脂肪组织包含多种不同类型的细胞，包括具有分化为多种细胞谱系潜力的脂肪来源干细胞（ASC），因此在开发再生医学疗法方面具有巨大潜力。目前，对于瘢痕尚无金标准治疗方法，伤口愈合受损仍是全球临床医生面临的一项挑战。本综述在讨论ASC的特性及其在组织工程、瘢痕形成和伤口愈合方面的前景应用之前，先描述了目前对脂肪组织的起源、不同类型、解剖位置和遗传学的认识。
