Fragopoulou Elizabeth, Antonopoulou Smaragdi
School of Health Science and Education, Department of Nutrition and Dietetics, Harokopio University, Greece.
School of Health Science and Education, Department of Nutrition and Dietetics, Harokopio University, Greece.
Clin Chim Acta. 2020 Nov;510:160-169. doi: 10.1016/j.cca.2020.07.013. Epub 2020 Jul 10.
Although, three decades have pasted from the introduction of "French Paradox", is still an issue for debate. Epidemiology supports the J-shaped relationship between wine consumption and vascular events as well as cardiovascular mortality with a maximum protection at 21 g of alcohol consumption in the form of wine per day. Nevertheless, the aforementioned studies have used an observational design that raises concerns about potential confounding. Randomized clinical studies may provide data to end the controversy and in parallel with in vitro experiments to elucidate the mechanisms by which wine affects cardiovascular disease. In this concept, this review aims to address the presence of bioactive wine micro constituents, their potential mechanisms of action and also to summarize the cardio-protective effects of wine intake based on clinical trials. The role of wine micro-constituents in inflammation and haemostasis is discussed in detail.
尽管自“法国悖论”提出已过去三十年，但这仍是一个有待辩论的问题。流行病学支持葡萄酒消费与血管事件以及心血管死亡率之间呈J形关系，每天饮用21克酒精含量的葡萄酒形式时具有最大保护作用。然而，上述研究采用的是观察性设计，这引发了对潜在混杂因素的担忧。随机临床研究可能会提供数据以结束这场争论，并与体外实验并行，以阐明葡萄酒影响心血管疾病的机制。在此概念下，本综述旨在探讨生物活性葡萄酒微量成分的存在、其潜在作用机制，并基于临床试验总结葡萄酒摄入的心脏保护作用。详细讨论了葡萄酒微量成分在炎症和止血中的作用。
