Yang Qiqi, Mao Huifang, Chen Xia, Zhang Yanji, Zhang Xiaolei, Liu Zhenzhen, Jiang Gongdao, Huang Wei
Hubei University of Chinese Medicine/The Co-innovation Center for Preventive Treatment of Disease of Acupuncture-moxibustion in Hubei Province.
Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.
Medicine (Baltimore). 2020 Jul 10;99(28):e20792. doi: 10.1097/MD.0000000000020792.
Myocardial ischemia reperfusion injury (MIRI) is 1 of the leading causes of disability and mortality worldwide in the cardiovascular diseases. Acupuncture has been widely applied in the treatment and prevention of cardiovascular diseases in recent years. This systematic review protocol aims to provide the methods for evaluating the efficacy of Neiguan (PC6)-based acupuncture pretreatment in animal models of MIRI.
The electronic databases of PubMed, Embase, Cochrane Library, as well as the Chinese databases such as China National Knowledge Infrastructure, Chinese Science and Technology Periodical Database, China Biology Medicine Database and WanFang Database will be searched from inception to November 2019. The outcome measures were myocardial infarct size, the level of ST-segment elevation, left ventricular ejection fraction, shortening fraction, arrhythmia score, cardiac enzymes, and cardiac troponin. Study inclusion, data extraction and quality assessment will be performed independently by 2 reviewers. RevMan 5.3 software will be used for the data synthesis and the quality of each study will be assessed independently by using the Collaborative Approach To Meta-Analysis And Review Of Animal Data From Experimental Studies checklist with minor modification.
This review will provide a high-quality synthesis of Neiguan (PC6)-based acupuncture pretreatment for MIRI in animal models CONCLUSIONS:: This systematic review will provide conclusive evidence for whether Neiguan (PC6)-based acupuncture pretreatment is an effective intervention in animal models of MIRI.
PROSPERO CRD42020175144.
心肌缺血再灌注损伤（MIRI）是全球心血管疾病中导致残疾和死亡的主要原因之一。近年来，针灸已广泛应用于心血管疾病的治疗和预防。本系统评价方案旨在提供评估基于内关穴（PC6）的针刺预处理对MIRI动物模型疗效的方法。
将检索PubMed、Embase、Cochrane图书馆等电子数据库，以及中国知网、中国科技期刊数据库、中国生物医学数据库和万方数据库等中文数据库，检索时间从建库至2019年11月。观察指标为心肌梗死面积、ST段抬高程度、左心室射血分数、缩短分数、心律失常评分、心肌酶和心肌肌钙蛋白。纳入研究、数据提取和质量评估将由2名研究者独立进行。将使用RevMan 5.3软件进行数据合成，并使用《实验研究动物数据的Meta分析与综述协作方法》清单经微小修改后独立评估每项研究的质量。
本综述将为基于内关穴（PC6）的针刺预处理对MIRI动物模型的疗效提供高质量的综合分析。结论：本系统评价将为基于内关穴（PC6）的针刺预处理在MIRI动物模型中是否为有效干预措施提供确凿证据。
PROSPERO CRD42020175144。
