Regenerative Medicine Research Center, West China Hospital, Sichuan University, Keyuan Road 4, Gaopeng Street, Chengdu, Sichuan, 610041, People's Republic of China.
Dushu Lake Hospital Affiliated to Soochow University, Chongwen Road 9, Suzhou, 215000, Jiangsu, China.
J Cardiovasc Transl Res. 2023 Jun;16(3):644-661. doi: 10.1007/s12265-022-10346-6. Epub 2023 Jan 23.
Acupuncture point specificity has been recognized as a key scientific issue in traditional Chinese medicine (TCM), but there is limited clinical trial or animal study to verify the characteristics of PC6, BL15, and ST36 in the protection from myocardial injury. We aimed to compare the effects among these three acupoints on the acute myocardial infarction mice model and to explore possible mechanisms for the first time. We found that PC6 is the most appropriate acupoint to deliver efficacy and safety to treat acute MI in mice. BL15 stimulation improved the systolic function, but increased the risk of arrhythmia. ST36 only slightly attenuated systolic function and had no effect on arrhythmia during MI. RNA profiles of skin tissue in local acupoints demonstrated that the most altered DEGs and related pathways may partly support its best effects of PC6 treatment on MI injury, and support the observed phenomenon of the acupoint specificity.
穴位特异性已被认为是传统中医（TCM）的一个关键科学问题，但目前还缺乏临床试验或动物研究来验证 PC6、BL15 和 ST36 在心肌损伤保护方面的特点。我们旨在首次比较这三个穴位对急性心肌梗死小鼠模型的影响，并探索可能的机制。我们发现 PC6 是最适合发挥疗效和安全性来治疗急性 MI 的穴位。BL15 刺激可改善收缩功能，但增加心律失常的风险。ST36 仅轻度减弱收缩功能，对 MI 期间的心律失常无影响。局部穴位皮肤组织的 RNA 谱表明，变化最明显的 DEGs 和相关通路可能部分支持 PC6 治疗对 MI 损伤的最佳效果，并支持观察到的穴位特异性现象。
