Li Zhouxiao, Cheng Ye, Wu Fan, Wu Liangliang, Cao Hongyong, Wang Qian, Tang Weiwei
Department of Hand Surgery, Plastic Surgery and Aesthetic Surgery, Ludwig-Maximilians University, Munich, Germany.
Department of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu China.
Biomark Res. 2020 Jul 10;8:25. doi: 10.1186/s40364-020-00204-5. eCollection 2020.
Circular RNAs (circRNAs) are covalently linked RNAs that exhibit individual strand with a closed-loop framework compared with a conserving, steady and abundant linear counterpart. In recent years, as high-throughput sequencing advancement has been developing, functional circRNAs have been increasingly recognized, and more extensive analyses expounded their effect on different diseases. However, the study on the function of circRNAs in the immune system remains insufficient. This study discusses the basic principles of circRNAs regulation and the systems involved in physiology-related and pathology-related processes. The effect of circRNAs on immune regulation is elucidated. The ongoing development of circRNAs and basic immunology has multiplied their potential in treating diseases. Such perspective will summarize the status and effect of circRNAs on various immune cells in cancer, autoimmune diseases and infections. Moreover, this study will primarily expound the system of circRNAs in T lymphocytes, macrophages and other immune cells, which creates a novel perspective and lay a theoretical basis for treating diseases.
环状RNA（circRNAs）是一种共价连接的RNA，与保守、稳定且丰富的线性对应物相比，其单链呈现闭环结构。近年来，随着高通量测序技术的不断发展，功能性环状RNA越来越受到关注，更多广泛的分析阐述了它们对不同疾病的影响。然而，关于环状RNA在免疫系统中功能的研究仍不充分。本研究讨论了环状RNA调控的基本原理以及参与生理相关和病理相关过程的系统。阐明了环状RNA对免疫调节的作用。环状RNA和基础免疫学的不断发展增加了它们在疾病治疗中的潜力。该观点将总结环状RNA在癌症、自身免疫性疾病和感染中对各种免疫细胞的状态和作用。此外，本研究将主要阐述环状RNA在T淋巴细胞、巨噬细胞和其他免疫细胞中的系统，为疾病治疗创造新的视角并奠定理论基础。
