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抗Ro(SSA)阳性类风湿关节炎(RA):一组D-青霉胺副作用发生率高的临床血清学患者。

Anti-Ro(SSA) positive rheumatoid arthritis (RA): a clinicoserological group of patients with high incidence of D-penicillamine side effects.

作者信息

Moutsopoulos H M, Skopouli F N, Sarras A K, Tsampoulas C, Mavridis A K, Constantopoulos S H, Maddison P J

出版信息

Ann Rheum Dis. 1985 Apr;44(4):215-9. doi: 10.1136/ard.44.4.215.

DOI:10.1136/ard.44.4.215
PMID:3872635
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1001615/
Abstract

The clinical, laboratory, histological, and radiological manifestations of 90 Greek patients with anti-Ro(SSA) negative rheumatoid arthritis (RA) were compared with those of 15 Greek patients with anti-Ro(SSA) positive RA. Anti-Ro(SSA) positive RA patients had the same articular and extra-articular manifestations as anti-Ro(SSA) negative patients. However, they were predominantly females with lower rheumatoid factor titres and a high incidence of positive minor salivary gland biopsy specimens for Sjögren's syndrome. Finally, anti-Ro(SSA) positive RA patients frequently experienced penicillamine side effects.

摘要

将90例抗Ro(SSA)阴性类风湿性关节炎(RA)希腊患者的临床、实验室、组织学和放射学表现与15例抗Ro(SSA)阳性RA希腊患者的表现进行了比较。抗Ro(SSA)阳性RA患者与抗Ro(SSA)阴性患者具有相同的关节和关节外表现。然而,他们主要为女性,类风湿因子滴度较低,小唾液腺活检标本中干燥综合征阳性的发生率较高。最后,抗Ro(SSA)阳性RA患者经常出现青霉胺副作用。

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1
Anti-Ro(SSA) positive rheumatoid arthritis (RA): a clinicoserological group of patients with high incidence of D-penicillamine side effects.抗Ro(SSA)阳性类风湿关节炎(RA):一组D-青霉胺副作用发生率高的临床血清学患者。
Ann Rheum Dis. 1985 Apr;44(4):215-9. doi: 10.1136/ard.44.4.215.
2
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3
D-penicillamine toxicity in Greek patients with rheumatoid arthritis: anti-Ro(SSA) antibodies and cryoglobulinemia are predictive factors.希腊类风湿关节炎患者中的青霉胺毒性:抗Ro(SSA)抗体和冷球蛋白血症是预测因素。
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本文引用的文献

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1958 Revision of diagnostic criteria for rheumatoid arthritis.1958年类风湿关节炎诊断标准修订版。
Bull Rheum Dis. 1958 Dec;9(4):175-6.
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Correlative histologic and serologic findings of sicca syndrome in patients with systemic lupus erythematosus.系统性红斑狼疮患者干燥综合征的相关组织学和血清学发现。
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Sjögren's syndrome (Sicca syndrome): current issues.干燥综合征(口眼干燥综合征):当前问题
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Ro(SSA) and La(SSB) antibodies in the clinical spectrum of Sjögren's syndrome.干燥综合征临床谱中的Ro(SSA)和La(SSB)抗体
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Serological findings in patients with "ANA-negative" systemic lupus erythematosus.“抗核抗体阴性”系统性红斑狼疮患者的血清学检查结果
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Serologic subsets in systemic lupus erythematosus: an examination of autoantibodies in relationship to clinical features of disease and HLA antigens.系统性红斑狼疮的血清学亚群:自身抗体与疾病临床特征及人类白细胞抗原的关系研究
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Inhibition of human helper T cell function in vitro by D-penicillamine and CuSO4.青霉胺和硫酸铜在体外对人辅助性T细胞功能的抑制作用。
J Clin Invest. 1980 May;65(5):1069-76. doi: 10.1172/JCI109759.
8
Antibodies to cellular antigens in Greek patients with autoimmune rheumatic diseases: anti-Ro(SSA) antibody a possible marker of penicillamine-D intolerance.希腊自身免疫性风湿疾病患者体内细胞抗原抗体:抗Ro(SSA)抗体可能是青霉胺不耐受的一个标志物。
Ann Rheum Dis. 1984 Apr;43(2):285-7. doi: 10.1136/ard.43.2.285.
9
Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine.抗核抗原自身抗体(ANA):其免疫生物学与医学
Adv Immunol. 1982;33:167-240. doi: 10.1016/s0065-2776(08)60836-6.
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Minor salivary gland involvement in Sjögren's syndrome.干燥综合征中的小唾液腺受累情况。
Oral Surg Oral Med Oral Pathol. 1974 Jan;37(1):64-74. doi: 10.1016/0030-4220(74)90160-1.