Dufrêne Yves F, Viljoen Albertus
Louvain Institute of Biomolecular Science and Technology, Catholic University of Louvain, Louvain-la-Neuve, Belgium.
Front Microbiol. 2020 Jun 25;11:1457. doi: 10.3389/fmicb.2020.01457. eCollection 2020.
Bacterial pathogens are equipped with specialized surface-exposed proteins that bind strongly to ligands on host tissues and biomaterials. These adhesins play critical roles during infection, especially during the early step of adhesion where the cells are exposed to physical stress. Recent single-molecule experiments have shown that staphylococci interact with their ligands through a wide diversity of mechanosensitive molecular mechanisms. Adhesin-ligand interactions are activated by tensile force and can be ten times stronger than classical non-covalent biological bonds. Overall these studies demonstrate that Gram-positive adhesins feature unusual stress-dependent molecular interactions, which play essential roles during bacterial colonization and dissemination. With an increasing prevalence of multidrug resistant infections caused by and , chemotherapeutic targeting of adhesins offers an innovative alternative to antibiotics.
细菌病原体配备有特殊的表面暴露蛋白，这些蛋白能与宿主组织和生物材料上的配体强烈结合。这些黏附素在感染过程中发挥关键作用，尤其是在细胞面临物理应激的早期黏附阶段。最近的单分子实验表明，葡萄球菌通过多种机械敏感分子机制与其配体相互作用。黏附素 - 配体相互作用由拉力激活，其强度可比经典的非共价生物键强十倍。总体而言，这些研究表明革兰氏阳性黏附素具有不寻常的应激依赖性分子相互作用，这在细菌定植和传播过程中起着至关重要的作用。随着由[未提及具体细菌名称]引起的多重耐药感染的患病率不断上升，针对黏附素的化学治疗为抗生素提供了一种创新的替代方法。
