Li Ya, Han Yijuan, Qu Mengyu, Chen Jia, Chen Xiaofeng, Geng Xueqing, Wang Zonghua, Chen Songbiao
Marine and Agricultural Biotechnology Laboratory, Institute of Oceanography, Minjiang University, Fuzhou, China.
State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, China.
Front Genet. 2020 Jun 26;11:661. doi: 10.3389/fgene.2020.00661. eCollection 2020.
Filamentous pathogens, such as phytopathogenic oomycetes and fungi, secrete a remarkable diversity of apoplastic effector proteins to facilitate infection, many of which are able to induce cell death in plants. Over the past decades, over 177 apoplastic cell death-inducing proteins (CDIPs) have been identified in filamentous oomycetes and fungi. An emerging number of studies have demonstrated the role of many apoplastic CDIPs as essential virulence factors. At the same time, apoplastic CDIPs have been documented to be recognized by plant cells as pathogen-associated molecular patterns (PAMPs). The recent findings of extracellular recognition of apoplastic CDIPs by plant leucine-rich repeat-receptor-like proteins (LRR-RLPs) have greatly advanced our understanding of how plants detect them and mount a defense response. This review summarizes the latest advances in identifying apoplastic CDIPs of plant pathogenic oomycetes and fungi, and our current understanding of the dual roles of apoplastic CDIPs in plant-filamentous pathogen interactions.
丝状病原体，如植物致病卵菌和真菌，会分泌种类繁多的质外体效应蛋白以促进感染，其中许多蛋白能够诱导植物细胞死亡。在过去几十年中，已在丝状卵菌和真菌中鉴定出177种以上的质外体细胞死亡诱导蛋白（CDIP）。越来越多的研究表明，许多质外体CDIP作为重要的致病因子发挥作用。与此同时，质外体CDIP已被证明被植物细胞识别为病原体相关分子模式（PAMP）。最近关于植物富含亮氨酸重复序列受体样蛋白（LRR-RLP）对质外体CDIP进行细胞外识别的发现，极大地推进了我们对植物如何检测它们并启动防御反应的理解。本综述总结了在鉴定植物致病卵菌和真菌的质外体CDIP方面的最新进展，以及我们目前对质外体CDIP在植物与丝状病原体相互作用中的双重作用的理解。
