Department of Cardiology, the Second Affiliated Hospital of Nanchang University, Nanchang, China.
Center for Prevention and Treatment of Cardiovascular Diseases, the Second Affiliated Hospital of Nanchang University, Nanchang, China.
Hypertens Res. 2020 Dec;43(12):1392-1402. doi: 10.1038/s41440-020-0509-y. Epub 2020 Jul 16.
The association between sleep conditions and arterial stiffness remains inconclusive. We aimed to investigate the relationship of sleep duration and quality with brachial-ankle pulse-wave velocity (baPWV) in hypertensive patients. A total of 14,485 hypertensive adults were included in this cross-sectional analysis. Information about sleep duration and quality was obtained via questionnaire. A baPWV level ≥1800 cm/s was defined as indicative of arterial stiffness. Compared with participants with a sleep duration <8 h per day, participants with a sleep duration ≥8 h per day had a significantly higher baPWV level (β = 13.7 cm/s; 95% CI: 3.9, 23.5) and a nonsignificantly higher prevalence of arterial stiffness (39.7% vs. 33.0%; OR, 1.08; 95% CI: 0.99-1.19). Similarly, compared with participants with good or medium sleep quality, participants with poor sleep quality had a significantly higher baPWV level (β = 16.3 cm/s; 95% CI: 0.1, 32.6) and a nonsignificantly greater prevalence of arterial stiffness (36.6% vs. 35.3%; OR, 1.13; 95% CI: 0.97-1.32). When sleep duration and quality were examined jointly, participants with a sleep duration ≥8 h and/or poor sleep quality had a significantly higher baPWV level (β = 14.4 cm/s; 95% CI: 5.3, 23.4) and a greater prevalence of arterial stiffness (38.8% vs. 32.7%; OR, 1.10; 95% CI: 1.01-1.20) than those with a sleep duration <8 h and good/medium sleep quality. In summary, among hypertensive patients, a longer sleep duration (≥8 h per day) and poor sleep quality were associated with higher baPWV levels and a higher prevalence of arterial stiffness.
睡眠条件与动脉僵硬度之间的关系仍不确定。我们旨在研究高血压患者的睡眠时间和质量与肱踝脉搏波速度（baPWV）之间的关系。共有 14485 名高血压成年人参与了这项横断面分析。通过问卷获得了关于睡眠时间和质量的信息。baPWV 水平≥1800cm/s 定义为动脉僵硬。与每天睡眠时间<8 小时的参与者相比，每天睡眠时间≥8 小时的参与者的 baPWV 水平显著更高（β=13.7cm/s；95%CI：3.9，23.5），且动脉僵硬的患病率也显著更高（39.7% vs. 33.0%；OR，1.08；95%CI：0.99-1.19）。同样，与睡眠质量良好或中等的参与者相比，睡眠质量差的参与者的 baPWV 水平显著更高（β=16.3cm/s；95%CI：0.1，32.6），且动脉僵硬的患病率也更高（36.6% vs. 35.3%；OR，1.13；95%CI：0.97-1.32）。当同时检查睡眠时间和质量时，睡眠时间≥8 小时和/或睡眠质量差的参与者的 baPWV 水平显著更高（β=14.4cm/s；95%CI：5.3，23.4），且动脉僵硬的患病率也更高（38.8% vs. 32.7%；OR，1.10；95%CI：1.01-1.20），高于睡眠时间<8 小时且睡眠质量良好/中等的参与者。综上所述，在高血压患者中，较长的睡眠时间（≥8 小时/天）和较差的睡眠质量与更高的 baPWV 水平和更高的动脉僵硬患病率相关。
