Obstetrics and Gynecology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, Naples, Italy
Curr Pharm Des. 2020;26(35):4509-4514. doi: 10.2174/1381612826666200721002022.
Besides hot-flushes, sleep disturbances increase around menopause, impacting on the quality of life. When hormone replacement therapy is contraindicated, it is necessary to provide alternative treatments.
This study aimed to observe the effects of an herbal remedy from pollen extracts and soy isoflavones for menopausal complaints, particularly on sleep disorders.
A six-month prospective observational study was performed in women in natural menopause suffering from menopausal symptoms and sleep disturbances. Three groups were compared: 57 women receiving two tablets/ day containing herbal remedy from pollen extracts (group A), 60 women receiving one tablet/day containing isoflavones 60 mg (group B), 47 women not receiving any treatment (group C). At 3 (T3) and 6 months (T6), the daily number of hot-flushes, Kupperman index for menopausal symptoms, the Pittsburgh Sleep Quality Index (PSQI) test were assessed.
Both groups A and B showed a significant improvement of hot flushes (p<0.001) and Kuppermann Index (p<0.001) from T0 to T3 and from T0 to T6. No significant differences between treatment groups were found at T3, while at T6 group A showed greater decrease of daily hot flashes and better improvement of Kupperman Index as compared to group B (respectively, -48.8% versus -18.4% and -24.4% versus -15.4%; p<0.001). Improvement of global sleep quality was more evident in the pollen treated group compared to isoflavones group at both three (-24.7% versus -9.3%, p<0.001) and six (-52.9% vs -4.0%; p<0.001) months, mainly for the scores related to subjective sleep quality, sleep latency and habitual sleep efficiency.
Non-hormonal treatments can effectively be used in symptomatic menopausal women: among these, after six months of treatment, pollen extracts might achieve a better improvement of hot flushes, sleep disturbances and menopause-related symptoms than soy isoflavones. Herbal remedy from pollen extracts is mainly effective when the quality of sleep is the most disturbing complaint.
除热潮外，睡眠障碍也会在围绝经期增加，影响生活质量。当激素替代疗法不适用时，需要提供替代治疗。
本研究旨在观察花粉提取物和大豆异黄酮的草药疗法对更年期主诉的影响，特别是对睡眠障碍的影响。
对患有更年期症状和睡眠障碍的自然绝经后妇女进行了为期 6 个月的前瞻性观察研究。比较了三组：57 名妇女每天服用两片含有花粉提取物的草药制剂（组 A），60 名妇女每天服用一片含有 60 毫克异黄酮的制剂（组 B），47 名妇女未接受任何治疗（组 C）。在 3 个月（T3）和 6 个月（T6）时，评估每日热潮次数、更年期症状 Kupperman 指数、匹兹堡睡眠质量指数（PSQI）测试。
组 A 和组 B 的热潮（p<0.001）和 Kupperman 指数（p<0.001）均从 T0 到 T3 和从 T0 到 T6 显著改善。在 T3 时，治疗组之间没有发现显著差异，而在 T6 时，组 A 每日热潮次数减少和 Kupperman 指数改善均优于组 B（分别为-48.8%比-18.4%和-24.4%比-15.4%；p<0.001）。与异黄酮组相比，花粉治疗组在三个月（-24.7%比-9.3%，p<0.001）和六个月（-52.9%比-4.0%；p<0.001）时整体睡眠质量的改善更为明显，主要与主观睡眠质量、睡眠潜伏期和习惯性睡眠效率相关的评分有关。
非激素治疗可有效用于有症状的更年期妇女：在这些治疗中，经过 6 个月的治疗，花粉提取物可能比大豆异黄酮更能改善热潮、睡眠障碍和与更年期相关的症状。花粉提取物的草药疗法主要在睡眠质量最令人困扰时有效。
