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基于纳米颗粒的药物递送系统：一种对肿瘤患者友好的化疗方法。

Nanoparticle-Based Drug Delivery System: A Patient-Friendly Chemotherapy for Oncology.

作者信息

Yan Lina, Shen Jingjing, Wang Jinqiao, Yang Xiaoyan, Dong Shiyan, Lu Saijun

机构信息

Department of Rehabilitation Medicine, The First People's Hospital of Wenling, Wenzhou Medical University, Wenling, Zhejiang, China.

School of Civil Engineering and Architecture, Taizhou University, Taizhou, Zhejiang, China.

出版信息

Dose Response. 2020 Jul 10;18(3):1559325820936161. doi: 10.1177/1559325820936161. eCollection 2020 Jul-Sep.

DOI:10.1177/1559325820936161
PMID:32699536
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7357073/
Abstract

Chemotherapy is widely used to treat cancer. The toxic effect of conventional chemotherapeutic drugs on healthy cells leads to serious toxic and side effects of conventional chemotherapy. The application of nanotechnology in tumor chemotherapy can increase the specificity of anticancer agents, increase the killing effect of tumors, and reduce toxic and side effects. Currently, a variety of formulations based on nanoparticles (NPs) for delivering chemotherapeutic drugs have been put into clinical use, and several others are in the stage of development or clinical trials. In this review, after briefly introducing current cancer chemotherapeutic methods and their limitations, we describe the clinical applications and advantages and disadvantages of several different types of NPs-based chemotherapeutic agents. We have summarized a lot of information in tables and figures related to the delivery of chemotherapeutic drugs based on NPs and the design of NPs with active targeting capabilities.

摘要

化疗被广泛用于治疗癌症。传统化疗药物对健康细胞的毒性作用导致了传统化疗严重的毒副作用。纳米技术在肿瘤化疗中的应用可以提高抗癌药物的特异性，增强肿瘤杀伤效果，并减少毒副作用。目前，多种基于纳米颗粒（NPs）的化疗药物递送制剂已投入临床使用，还有几种正处于研发或临床试验阶段。在本综述中，在简要介绍当前癌症化疗方法及其局限性之后，我们描述了几种不同类型的基于NPs的化疗药物的临床应用以及优缺点。我们在表格和图表中总结了大量与基于NPs的化疗药物递送以及具有主动靶向能力的NPs设计相关的信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd9/7357073/17be27eb8ba7/10.1177_1559325820936161-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd9/7357073/55a91ae8fcbe/10.1177_1559325820936161-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd9/7357073/60019afc01c9/10.1177_1559325820936161-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd9/7357073/4c43f984fdbd/10.1177_1559325820936161-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd9/7357073/dc9ebdd0228e/10.1177_1559325820936161-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd9/7357073/7e7377920e56/10.1177_1559325820936161-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd9/7357073/17be27eb8ba7/10.1177_1559325820936161-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd9/7357073/55a91ae8fcbe/10.1177_1559325820936161-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd9/7357073/60019afc01c9/10.1177_1559325820936161-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd9/7357073/4c43f984fdbd/10.1177_1559325820936161-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd9/7357073/dc9ebdd0228e/10.1177_1559325820936161-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd9/7357073/7e7377920e56/10.1177_1559325820936161-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bd9/7357073/17be27eb8ba7/10.1177_1559325820936161-fig6.jpg

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