Fu Man Shun, Drummond Rebecca A
Institute of Immunology & Immunotherapy, Institute of Microbiology & Infection, University of Birmingham, Birmingham B15 2TT, UK.
J Fungi (Basel). 2020 Jul 16;6(3):111. doi: 10.3390/jof6030111.
Monocytes are considered to play a central role in the pathogenesis of infection. Monocytes and monocyte-derived macrophages and dendritic cells are key components for the control of infection, but paradoxically they can also contribute to detrimental host responses and may even support fungal proliferation and dissemination. Simultaneously, the polysaccharide capsule can impair the functions of monocytes. Although monocytes are often seen as simple precursor cells, they also function as independent immune effector cells. In this review, we summarize these monocyte-specific functions during cryptococcal infection and the influence of on monocyte responses. We also cover the most recent findings on the functional and phenotypic heterogeneity of monocytes and discuss how new advanced technologies provide a platform to address outstanding questions in the field.
单核细胞被认为在感染的发病机制中起核心作用。单核细胞以及单核细胞衍生的巨噬细胞和树突状细胞是控制感染的关键组成部分，但矛盾的是，它们也可能导致有害的宿主反应，甚至可能支持真菌的增殖和扩散。同时，多糖荚膜会损害单核细胞的功能。尽管单核细胞通常被视为简单的前体细胞，但它们也作为独立的免疫效应细胞发挥作用。在本综述中，我们总结了隐球菌感染期间这些单核细胞特异性功能以及对单核细胞反应的影响。我们还涵盖了关于单核细胞功能和表型异质性的最新发现，并讨论了新的先进技术如何为解决该领域悬而未决的问题提供一个平台。
