Yu Xiaoling, Zhang Tian, Li Yuan
School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070, China.
State Key Laboratory of Silicate Materials for Architectures, Wuhan University of Technology, Wuhan 430070, China.
Polymers (Basel). 2020 Jul 23;12(8):1637. doi: 10.3390/polym12081637.
Fabrication of nerve conduits for perfectly repairing or replacing damaged peripheral nerve is an urgent demand worldwide, but it is also a formidable clinical challenge. In the last decade, with the rapid development of manufacture technologies, 3D printing and bioprinting have been becoming remarkable stars in the field of neural engineering. In this review, we explore that the biomaterial inks (hydrogels, thermoplastic, and thermoset polyesters and composite) and bioinks have been selected for 3D printing and bioprinting of peripheral nerve conduits. This review covers 3D manufacturing technologies, including extrusion printing, inkjet printing, stereolithography, and bioprinting with inclusion of cells, bioactive molecules, and drugs. Finally, an outlook on the future directions of 3D printing and 4D printing in customizable nerve therapies is presented.
制造能够完美修复或替换受损周围神经的神经导管是全球范围内的迫切需求，但这也是一项艰巨的临床挑战。在过去十年中，随着制造技术的迅速发展，3D打印和生物打印已成为神经工程领域的耀眼明星。在本综述中，我们探讨了用于周围神经导管3D打印和生物打印的生物材料墨水（水凝胶、热塑性塑料、热固性聚酯和复合材料）和生物墨水。本综述涵盖了3D制造技术，包括挤出打印、喷墨打印、立体光刻以及包含细胞、生物活性分子和药物的生物打印。最后，展望了3D打印和4D打印在定制神经治疗方面的未来发展方向。
