Department of Pediatrics and Neonatology, Guglielmo da Saliceto Hospital, 29121 Piacenza, Italy.
Department of Translational Medical Science-Pediatric Section, University "Federico II", 80131 Naples, Italy.
Int J Mol Sci. 2020 Jul 25;21(15):5275. doi: 10.3390/ijms21155275.
The increasing prevalence and severity of pediatric food allergies (FA) demands innovative preventive and therapeutic strategies. Emerging evidence suggests a pivotal role for the gut microbiome in modulating susceptibility to FA. Studies have demonstrated that alteration of gut microbiome could precede FA, and that particular microbial community structures early in life could influence also the disease course. The identification of gut microbiome features in pediatric FA patients is driving new prevention and treatment approaches. This review is focused on the potential role of the gut microbiome as a target for FA prevention and treatment.
儿童食物过敏(FA)的发病率和严重程度不断增加,这需要创新的预防和治疗策略。新出现的证据表明,肠道微生物组在调节食物过敏易感性方面起着关键作用。研究表明,肠道微生物组的改变可能先于食物过敏,而生命早期特定的微生物群落结构也可能影响疾病的进程。在儿科 FA 患者中识别肠道微生物组特征正在推动新的预防和治疗方法的出现。这篇综述集中讨论了肠道微生物组作为 FA 预防和治疗靶点的潜在作用。