Krutmann J, Berneburg M
IUF - Leibniz-Institut für umweltmedizinische Forschung, Auf'm Hennekamp 50, 40225, Düsseldorf, Deutschland.
Klinik und Poliklinik für Dermatologie, UKR - Universitätsklinikum Regensburg, Regensburg, Deutschland.
Hautarzt. 2021 Jan;72(1):2-5. doi: 10.1007/s00105-020-04747-4. Epub 2020 Dec 21.
Skin aging results from the interaction of genetic and nongenetic so-called exposomal, factors. Among the exposomal factors, chronic, life-long exposure to sunlight is of eminent importance for the development of skin aging characteristics. Importantly, photoaging of human skin is not only caused by ultraviolet (UV) B and A radiation, but is also the consequence of exposure to wavelengths beyond the UV spectrum. These include visible, i.e. blue light (400-440 nm) as well as the short part of infrared radiation, i.e. IRA (760-1200 nm). Here we summarize the scientific evidence supporting these conclusions and emphasize the resulting consequences for daily photoprotection of human skin. We also explain the clinical significance of the concept that is offered by the skin aging exposome, which e.g. takes into account the fact that sunlight interacts with other exposomal factors and that this interaction is important for photoaging of the skin.
皮肤老化是由遗传和非遗传的所谓暴露组因素相互作用导致的。在暴露组因素中，长期、终生暴露于阳光下对皮肤老化特征的形成至关重要。重要的是，人类皮肤的光老化不仅由紫外线B和紫外线A辐射引起，也是暴露于紫外线光谱以外波长的结果。这些波长包括可见光，即蓝光（400 - 440纳米）以及红外辐射的短波段，即IRA（760 - 1200纳米）。在此，我们总结支持这些结论的科学证据，并强调其对人类皮肤日常光防护的影响。我们还解释了皮肤老化暴露组概念的临床意义，例如它考虑到阳光与其他暴露组因素相互作用这一事实，且这种相互作用对皮肤光老化很重要。
