Gong Zhenxiang, Gao Rong, Ba Li, Liu Yang, Hou Hongyan, Zhang Min
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Brain Sci. 2023 Jan 26;13(2):205. doi: 10.3390/brainsci13020205.
A growing body of evidence suggests immune involvement in the pathology of multiple system atrophy (MSA). Research on detailed peripheral immune indices, however, is relatively sparse, and is one of the intriguing aspects of MSA yet to be elucidated. A total of 26 MSA patients and 56 age-and sex-matched healthy controls (HC) were enrolled in the current case-control study to delineate the peripheral immune traits of MSA patients. The ratio of CD4/CD8 T cells, natural killer cells, CD28 expression on both CD4 T cells and CD8 T cells increased in MSA patients compared to HC, but CD8 T cells and active marker (HLA-DR) expression on total T cells decreased ( < 0.05). This study sheds light on the dysregulation of cellular immunity in MSA, pointing to future mechanistic research.
越来越多的证据表明免疫参与了多系统萎缩（MSA）的病理过程。然而，关于详细外周免疫指标的研究相对较少，这是MSA尚未阐明的有趣方面之一。本病例对照研究共纳入了26例MSA患者和56例年龄及性别匹配的健康对照（HC），以描绘MSA患者的外周免疫特征。与HC相比，MSA患者的CD4/CD8 T细胞比值、自然杀伤细胞、CD4 T细胞和CD8 T细胞上的CD28表达增加，但CD8 T细胞和总T细胞上的活性标志物（HLA-DR）表达降低（<0.05）。这项研究揭示了MSA中细胞免疫的失调，为未来的机制研究指明了方向。
