Department of Immunology and Allergy, Medical University of Lodz, Lodz, Poland.
Clin Exp Allergy. 2020 Oct;50(10):1122-1126. doi: 10.1111/cea.13718. Epub 2020 Aug 26.
Human coronaviruses (HCoVs) such as HCoV-229E or OC43 are responsible for mild upper airway infections, whereas highly pathogenic HCoVs, including SARS-CoV, MERS-CoV and SARS-CoV-2, often evoke acute, heavy pneumonias. They tend to induce immune responses based on interferon and host inflammatory cytokine production and promotion of T1 immune profile. Less is known about their effect on T2-type immunity. Unlike human rhinoviruses (HRV) and Respiratory Syncytial Virus (RSV), HCoVs are not considered as a dominant risk factor of severe exacerbations of asthma, mostly T2-type chronic inflammatory disease. The relationship between coronaviruses and T2-type immunity, especially in asthma and allergy, is not well understood. This review aims to summarize currently available knowledge about the relationship of HCoVs, including novel SARS-CoV-2, with asthma and allergic inflammation.
人冠状病毒（HCoVs），如 HCoV-229E 或 OC43，可引起轻度上呼吸道感染，而高致病性 HCoVs，包括严重急性呼吸综合征冠状病毒（SARS-CoV）、中东呼吸综合征冠状病毒（MERS-CoV）和严重急性呼吸综合征冠状病毒 2（SARS-CoV-2），常引起急性重症肺炎。它们通常会诱导基于干扰素和宿主炎症细胞因子产生和促进 T1 免疫特征的免疫反应。关于它们对 T2 型免疫的影响，人们知之甚少。与人类鼻病毒（HRV）和呼吸道合胞病毒（RSV）不同，HCoVs 不被认为是哮喘等 T2 型慢性炎症性疾病严重恶化的主要危险因素。冠状病毒与 T2 型免疫之间的关系，特别是在哮喘和过敏方面，尚未得到很好的理解。这篇综述旨在总结目前关于 HCoVs（包括新型 SARS-CoV-2）与哮喘和过敏性炎症关系的相关知识。
