UOC di Nutrizione Clinica, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy.
Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy.
Nutrients. 2020 Aug 5;12(8):2345. doi: 10.3390/nu12082345.
Nutritional guidelines suggest specific energy and protein requirements for patients with cancer. However, cancer patients, often malnourished, use self-made or web-based diets to ameliorate the prognosis of their disease. This review aimed to investigate the associations between post-diagnostic diet and prognostic outcomes in cancer patients. A systematic literature search was performed in Pubmed and Web of Science databases from inception to 30 October 2019, based on fixed inclusion and exclusion criteria. The risk of bias was assessed. A total of 29 prospective studies was identified. Breast ( = 11), colorectal ( = 9), prostate ( = 8) cancers are the most studied. Low- fat diet, healthy quality diet, regular consumption of fiber such as vegetables and high-quality protein intake are beneficial while Western diet (WD) and high consumption of saturated fats could be associated with a higher risk of mortality. Bladder ( = 1), gynecological ( = 1), lung, stomach, and pancreatic cancers still remain almost unexplored. This systematic review suggested that detrimental dietary patterns such as WD should be avoided but none of the food categories (meat, dairy products) should be eliminated in cancer patients' diet. Further large prospective studies are needed to assess the role of post-diagnostic diet in patients with cancer.
营养指南建议癌症患者有特定的能量和蛋白质需求。然而,癌症患者往往营养不良,他们会采用自己制作的或基于网络的饮食来改善疾病的预后。本综述旨在调查癌症患者诊断后饮食与预后结果之间的关系。根据固定的纳入和排除标准,我们在 Pubmed 和 Web of Science 数据库中进行了系统的文献检索,检索时间从建库至 2019 年 10 月 30 日。我们评估了偏倚风险。共确定了 29 项前瞻性研究。研究最多的癌症类型为乳腺癌( = 11)、结直肠癌( = 9)、前列腺癌( = 8)。低脂饮食、健康优质饮食、规律摄入纤维(如蔬菜)和高质量蛋白质摄入有益,而西方饮食(WD)和大量摄入饱和脂肪可能与更高的死亡率风险相关。膀胱癌( = 1)、妇科癌症( = 1)、肺癌、胃癌和胰腺癌仍然几乎未被探索。本系统综述表明,应避免有害的饮食模式,如 WD,但癌症患者的饮食不应排除任何食物类别(肉类、奶制品)。需要进一步进行大型前瞻性研究来评估诊断后饮食在癌症患者中的作用。