Department of Sense Organs, Sapienza University of Rome, Rome, Italy.
Eur Rev Med Pharmacol Sci. 2020 Aug;24(15):7946-7952. doi: 10.26355/eurrev_202008_22477.
The awareness of audio-vestibular side effects of drugs, such as hearing loss, tinnitus, dizziness and vertigo, has widely increased in the recent years. The present guide represents an update of the previous documents published by the authors in 2005 and 2011 on drug-induced ototoxicity and vestibulotoxicity.
The authors performed a comprehensive analysis of audio-vestibular side effects of commercially available drugs based on the British National Formulary, a pharmaceutical reference book that contains a wide range of useful information and advice on prescription and pharmacology.
Commercially available drugs and their active principles have been classified based on their audio-vestibular side effects, as reported by the pharmaceutical companies and/or health agencies. Drugs have been categorized based on the field of application, the therapeutic indication and the pharmacological properties.
General practitioners, otolaryngology, neurology and audiology specialists should be aware of possible audio-vestibular side effects of drugs, such as hearing loss, tinnitus, dizziness and vertigo. The present guide represents a practical tool to rapidly identify potential audio-vestibular side effects of drugs as reported by the pharmaceutical companies and/or health agencies.
近年来，人们对药物的耳毒性和前庭毒性等听觉-平衡副作用的认识有了显著提高，例如听力损失、耳鸣、头晕和眩晕。本指南是作者在 2005 年和 2011 年发表的关于药物性耳毒性和前庭毒性的先前文件的更新。
作者根据英国国家处方集（British National Formulary）对市售药物的听觉-平衡副作用进行了全面分析，这是一本医药参考书，包含了处方和药理学方面的广泛有用信息和建议。
根据制药公司和/或卫生机构的报告，市售药物及其活性成分已根据其听觉-平衡副作用进行了分类。药物根据应用领域、治疗适应证和药理学特性进行分类。
全科医生、耳鼻喉科医生、神经科医生和听力学专家应该意识到药物可能引起的听觉-平衡副作用，如听力损失、耳鸣、头晕和眩晕。本指南是一个实用工具，可以快速识别制药公司和/或卫生机构报告的潜在药物听觉-平衡副作用。
