Laboratory Sciences, Department of Medical, Faculty of Allied Health Sciences, Health Sciences Center (HSC), Kuwait University, Jabriya, Kuwait.
Department of Microbiology, College of Medicine, Kuwait University, Jabriya, Kuwait.
Front Cell Infect Microbiol. 2024 Jun 26;14:1410115. doi: 10.3389/fcimb.2024.1410115. eCollection 2024.
Antibiotic resistance, a known global health challenge, involves the flow of bacteria and their genes among animals, humans, and their surrounding environment. It occurs when bacteria evolve and become less responsive to the drugs designated to kill them, making infections harder to treat. Despite several obstacles preventing the spread of genes and bacteria, pathogens regularly acquire novel resistance factors from other species, which reduces their ability to prevent and treat such bacterial infections. This issue requires coordinated efforts in healthcare, research, and public awareness to address its impact on human health worldwide. This review outlines how recent advances in gene editing technology, especially CRISPR/Cas9, unveil a breakthrough in combating antibiotic resistance. Our focus will remain on the relationship between CRISPR/cas9 and its impact on antibiotic resistance and its related infections. Moreover, the prospects of this new advanced research and the challenges of adopting these technologies against infections will be outlined by exploring its different derivatives and discussing their advantages and limitations over others, thereby providing a corresponding reference for the control and prevention of the spread of antibiotic resistance.
抗生素耐药性是一个已知的全球健康挑战，涉及细菌及其基因在动物、人类及其周围环境中的流动。当细菌进化并对旨在杀死它们的药物反应减弱时，就会发生这种情况，从而使感染更难治疗。尽管有几个因素可以阻止基因和细菌的传播，但病原体经常从其他物种获得新的耐药因素，从而降低了预防和治疗此类细菌感染的能力。这个问题需要在医疗保健、研究和公众意识方面协调努力，以解决其对全球人类健康的影响。本综述概述了基因编辑技术，特别是 CRISPR/Cas9 的最新进展如何为对抗抗生素耐药性带来突破。我们的重点将仍然放在 CRISPR/cas9 及其对抗生素耐药性及其相关感染的影响之间的关系上。此外，通过探索其不同的衍生物并讨论它们相对于其他衍生物的优势和局限性，概述这项新的先进研究的前景和采用这些技术对抗感染的挑战，从而为控制和预防抗生素耐药性的传播提供相应的参考。
