文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期,新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

通过高场、高频和可调温度的交流磁强计探索动态磁滞回线在磁热疗特性研究中的潜力。

Exploring the potential of the dynamic hysteresis loops via high field, high frequency and temperature adjustable AC magnetometer for magnetic hyperthermia characterization.

机构信息

Fundación BCMaterials - Basque Center for Materials, Applications and Nanostructures, Leioa, Spain.

Elektrizitatea eta Elektronika Saila, Facultad de Ciencia y Tecnología, Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Leioa, Spain.

出版信息

Int J Hyperthermia. 2020;37(1):976-991. doi: 10.1080/02656736.2020.1802071.


DOI:10.1080/02656736.2020.1802071
PMID:32781865
Abstract

AIM: The Specific Absorption Rate (SAR) is the key parameter to optimize the effectiveness of magnetic nanoparticles in magnetic hyperthermia. AC magnetometry arises as a powerful technique to quantify the SAR by computing the hysteresis loops' area. However, currently available devices produce quite limited magnetic field intensities, below 45mT, which are often insufficient to obtain major hysteresis loops and so a more complete and understandable magneticcharacterization. This limitation leads to a lack of information concerning some basic properties, like the maximum attainable (SAR) as a function of particles' size and excitation frequencies, or the role of the mechanical rotation in liquid samples. METHODS: To fill this gap, we have developed a versatile high field AC magnetometer, capable of working at a wide range of magnetic hyperthermia frequencies (100 kHz - 1MHz) and up to field intensities of 90mT. Additionally, our device incorporates a variable temperature system for continuous measurements between 220 and 380 K. We have optimized the geometrical properties of the induction coil that maximize the generated magnetic field intensity. RESULTS: To illustrate the potency of our device, we present and model a series of measurements performed in liquid and frozen solutions of magnetic particles with sizes ranging from 16 to 29 nm. CONCLUSION: We show that AC magnetometry becomes a very reliable technique to determine the effective anisotropy constant of single domains, to study the impact of the mechanical orientation in the SAR and to choose the optimal excitation parameters to maximize heating production under human safety limits.

摘要

目的:比吸收率(SAR)是优化磁纳米粒子在磁热疗中有效性的关键参数。交流磁强计是一种通过计算磁滞回线面积来定量 SAR 的强大技术。然而,目前可用的设备产生的磁场强度相当有限,低于 45mT,这通常不足以获得主要的磁滞回线,因此需要更完整和可理解的磁特性。这种限制导致缺乏有关一些基本特性的信息,例如作为粒子尺寸和激励频率函数的最大可达到(SAR),或者机械旋转在液体样品中的作用。

方法:为了弥补这一空白,我们开发了一种通用的高场交流磁强计,能够在广泛的磁热疗频率(100 kHz-1MHz)下工作,并能达到 90mT 的磁场强度。此外,我们的设备还集成了一个可变温度系统,可在 220 至 380 K 之间进行连续测量。我们优化了感应线圈的几何形状,以最大限度地提高产生的磁场强度。

结果:为了说明我们设备的功效,我们展示并模拟了一系列在尺寸为 16 至 29nm 的磁性粒子的液态和冷冻溶液中进行的测量。

结论:我们表明,交流磁强计是一种非常可靠的技术,可以确定单畴的有效各向异性常数,研究机械取向对 SAR 的影响,并选择最佳激励参数,以在人体安全限制下最大限度地提高加热效果。

相似文献

[1]
Exploring the potential of the dynamic hysteresis loops via high field, high frequency and temperature adjustable AC magnetometer for magnetic hyperthermia characterization.

Int J Hyperthermia. 2020

[2]
Hysteresis losses and specific absorption rate measurements in magnetic nanoparticles for hyperthermia applications.

Biochim Biophys Acta Gen Subj. 2016-12-14

[3]
Specific absorption rate dependence on temperature in magnetic field hyperthermia measured by dynamic hysteresis losses (ac magnetometry).

Nanotechnology. 2015-1-9

[4]
How size, shape and assembly of magnetic nanoparticles give rise to different hyperthermia scenarios.

Nanoscale. 2021-10-1

[5]
Induction heating studies of dextran coated MgFe2O4 nanoparticles for magnetic hyperthermia.

Dalton Trans. 2013-1-28

[6]
Bacterially synthesized ferrite nanoparticles for magnetic hyperthermia applications.

Nanoscale. 2014-11-7

[7]
In silico evaluation of adverse eddy current effects in preclinical tests of magnetic hyperthermia.

Comput Methods Programs Biomed. 2022-8

[8]
In silico assessment of collateral eddy current heating in biocompatible implants subjected to magnetic hyperthermia treatments.

Int J Hyperthermia. 2021

[9]
Using kinetic Monte Carlo simulations to design efficient magnetic nanoparticles for clinical hyperthermia.

Med Phys. 2022-1

[10]
Focused RF hyperthermia using magnetic fluids.

Med Phys. 2009-5

引用本文的文献

[1]
From Bimetallic Oleates to Customized Biomedical Nanoplatforms: A Versatile Approach for the Multidoping of Ferrites.

ACS Appl Mater Interfaces. 2025-5-21

[2]
Heating Efficiency of Different Magnetotactic Bacterial Species: Influence of Magnetosome Morphology and Chain Arrangement.

ACS Appl Mater Interfaces. 2024-12-11

[3]
Multifunctional effects in magnetic nanoparticles for precision medicine: combining magnetic particle thermometry and hyperthermia.

Nanoscale Adv. 2023-7-5

[4]
Incorporation of Tb and Gd improves the diagnostic functionality of magnetotactic bacteria.

Mater Today Bio. 2023-5-24

[5]
Tuning the Magnetic Response of Magnetospirillum magneticum by Changing the Culture Medium: A Straightforward Approach to Improve Their Hyperthermia Efficiency.

ACS Appl Mater Interfaces. 2023-1-11

[6]
The Hybrid System for the Magnetic Characterization of Superparamagnetic Nanoparticles.

Sensors (Basel). 2022-11-17

[7]
Efficient Magneto-Luminescent Nanosystems based on Rhodamine-Loaded Magnetite Nanoparticles with Optimized Heating Power and Ideal Thermosensitive Fluorescence.

ACS Appl Mater Interfaces. 2022-10-27

[8]
Time-dependent AC magnetometry and chain formation in magnetite: the influence of particle size, initial temperature and the shortening of the relaxation time by the applied field.

Nanoscale Adv. 2021-8-13

[9]
Magnetic Hyperthermia Enhancement in Iron-based Materials Driven by Carbon Support Interactions.

Chemistry. 2022-12-1

[10]
A Milestone in the Chemical Synthesis of FeO Nanoparticles: Unreported Bulklike Properties Lead to a Remarkable Magnetic Hyperthermia.

Chem Mater. 2021-11-23

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索