Miao Xinbao, Yang Shuhui, Zhu Jinjin, Gong Zhe, Wu Dongze, Hong Juncong, Cai Kaiwen, Wang Jiying, Fang Xiangqian, Lu Jiye, Jiang Guoqiang
Department of Spinal Surgery, The First Affiliated Hospital of Ningbo University, Ningbo 315000, Zhejiang, China.
School of Materials Science and Engineering, Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang, China.
Regen Biomater. 2023 May 11;10:rbad040. doi: 10.1093/rb/rbad040. eCollection 2023.
Polymethylmethacrylate (PMMA) bone cement extensively utilized for the treatment of osteoporotic vertebral compression fractures due to its exceptional handleability and mechanical properties. Nevertheless, the clinical application of PMMA bone cement is restricted by its poor bioactivity and excessively high modulus of elasticity. Herein, mineralized small intestinal submucosa (mSIS) was incorporated into PMMA to prepare a partially degradable bone cement (mSIS-PMMA) that provided suitable compressive strength and reduced elastic modulus compared to pure PMMA. The ability of mSIS-PMMA bone cement to promote the attachment, proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells was shown through cellular experiments carried out , and an animal osteoporosis model validated its potential to improve osseointegration. Considering these benefits, mSIS-PMMA bone cement shows promising potential as an injectable biomaterial for orthopedic procedures that require bone augmentation.
聚甲基丙烯酸甲酯（PMMA）骨水泥因其出色的可操作性和机械性能而被广泛用于治疗骨质疏松性椎体压缩骨折。然而，PMMA骨水泥的临床应用受到其生物活性差和弹性模量过高的限制。在此，将矿化小肠黏膜下层（mSIS）掺入PMMA中，制备出一种部分可降解的骨水泥（mSIS-PMMA），与纯PMMA相比，它具有合适的抗压强度并降低了弹性模量。通过进行细胞实验，证明了mSIS-PMMA骨水泥促进骨髓间充质干细胞附着、增殖和成骨分化的能力，并且动物骨质疏松模型验证了其改善骨整合的潜力。考虑到这些优点，mSIS-PMMA骨水泥作为一种用于需要骨增强的骨科手术的可注射生物材料显示出有前景的潜力。
