de Soysa Ann Kristin H, Klevjer Marie, Grill Valdemar, Mostad Ingrid Løvold
Department of Clinical Nutrition and Speech-Language Therapy, Clinic of Clinical Services, St. Olavs Hospital - Trondheim University Hospital, Trondheim, Norway.
Department of Mathematical Sciences, Faculty of Information Technology and Electrical Engineering, Norwegian University of Science and Technology, Trondheim, Norway.
Metabol Open. 2019 Feb 19;1:3-6. doi: 10.1016/j.metop.2019.02.001. eCollection 2019 Mar.
The metabolic consequences of carrying a FTO obesity-promoting risk allele have not been fully elucidated and may be confounded by obesity . Against this background, we investigated the impact of FTO allele (SNP rs9939609) on fasting and postprandial energy expenditure and fasting substrate expenditure in a study population of uniformly and similarly obese individuals.
We studied a similar number of participants with BMI classes 2-3 (median BMI 42.8 kg/m) who were either homozygote for the non-risk allele TT (n = 33, numbers increased by enrichment), heterozygote (AT) (n = 32), or homozygote for the risk allele AA (n = 35).
Basal metabolic rate and postprandial energy expenditure did not differ between FTO-groups. However, fasting respiratory quotient (RQ) was increased in those carrying ≥1 risk allele (p = 0.008), whereas postprandial RQ was not.
In this study population, the FTO-risk allele associates with fasting reduced fat and increased carbohydrate oxidation.
携带FTO肥胖促进风险等位基因的代谢后果尚未完全阐明，且可能因肥胖而混淆。在此背景下，我们在一个体重一致且相似的肥胖个体研究人群中，研究了FTO等位基因（单核苷酸多态性rs9939609）对空腹和餐后能量消耗以及空腹底物消耗的影响。
我们研究了数量相似的BMI等级为2 - 3（中位BMI为42.8 kg/m）的参与者，他们要么是无风险等位基因TT的纯合子（n = 33，通过富集增加数量），杂合子（AT）（n = 32），要么是风险等位基因AA的纯合子（n = 35）。
FTO组之间的基础代谢率和餐后能量消耗没有差异。然而，携带≥1个风险等位基因的个体空腹呼吸商（RQ）升高（p = 0.008），而餐后RQ没有升高。
在这个研究人群中，FTO风险等位基因与空腹时脂肪减少和碳水化合物氧化增加有关。
