Sindhu Rakesh K, Gupta Rubal, Wadhera Gaurish, Kumar Pradeep
Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, India.
Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, Faculty of Health Sciences, School of Therapeutic Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.
Gels. 2022 Feb 7;8(2):97. doi: 10.3390/gels8020097.
This study examined the most recent advancements in nanogel production and drug delivery. Phytochemistry is a discipline of chemistry that studies herbal compounds. Herbal substances have aided in the development of innovative remedies for a wide range of illnesses. Several of these compounds are forbidden from being used in medications due to broad medical characteristics and pharmacokinetics. A variety of new technical approaches have been investigated to ameliorate herbal discoveries in the pharmaceutical sector. The article focuses on the historical data for herb-related nanogels that are used to treat a variety of disorders with great patient compliance, delivery rate, and efficacy. Stimulus-responsive nanogels such as temperature responsive and pH-responsive systems are also discussed. Nanogel formulations, which have been hailed as promising targets for drug delivery systems, have the ability to alter the profile of a drug, genotype, protein, peptide, oligosaccharide, or immunogenic substance, as well as its ability to cross biological barriers, biodistribution, and pharmacokinetics, improving efficacy, safety, and patient cooperation.
本研究考察了纳米凝胶制备及药物递送方面的最新进展。植物化学是化学的一个分支学科,研究植物化合物。植物物质有助于开发针对多种疾病的创新疗法。由于广泛的医学特性和药代动力学,其中一些化合物被禁止用于药物。人们研究了多种新技术方法,以改进制药领域的植物学发现。本文重点关注与草药相关的纳米凝胶的历史数据,这些纳米凝胶用于治疗多种疾病,具有很高的患者依从性、递送率和疗效。还讨论了刺激响应型纳米凝胶,如温度响应和pH响应系统。纳米凝胶制剂被誉为药物递送系统的有前景的靶点,它能够改变药物、基因型、蛋白质、肽、寡糖或免疫原性物质的特性,以及其穿越生物屏障、生物分布和药代动力学的能力,从而提高疗效、安全性和患者配合度。