Ning Yanzhe, Li Kuangshi, Zhang Yong, Chen Pei, Yin Dongqing, Zhu Hong, Jia Hongxiao
The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Department of Rehabilitation, Dongzhimen Hospital, The First Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, China.
Front Psychiatry. 2020 Aug 6;11:780. doi: 10.3389/fpsyt.2020.00780. eCollection 2020.
Numerous studies have confirmed that long-term shift work is not only associated with increased health problems and acute impact on safety but also with impaired cognitive abilities. However, very little is known about effects of shift work on cognition-related brain resting-state networks. The aim of this study was to explore the effects of shift work disorder (SWD) on granger causality connection among resting-state brain networks.
Thirty patients with SWD and 25 matched healthy subjects were recruited to undergo the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and resting-state fMRI scanning. We employed independent component analysis (ICA) to extract resting-state brain networks and granger causality analysis (GCA) to characterize the difference of granger causality connection among cognition-related resting-state brain networks.
Compared with healthy subjects, patients with SWD showed impairments on the attention and immediate memory. Seven resting-state brain networks were identified, and patients with SWD showed more numerous granger causality connections in comparison with healthy subjects. Two-sample test results showed that there were significantly increased inflows from the anterior default mode network (aDMN) to sensorimotor network (SMN) and left frontoparietal network (LFPN) to salience network (SN). Correlation analyses showed that the increased inflows from aDMN to SMN were negatively associated with the score of attention, while LFPN to SN were negatively associated with the score of visuospatial/constructional ability.
This study indicates that SWD impairs cognitive performance, and the specific intrinsic brain granger causality connectivity among resting-state networks in SWD patients is affected after long-term shift works.
大量研究证实，长期轮班工作不仅与健康问题增加、对安全的急性影响有关，还与认知能力受损有关。然而，关于轮班工作对与认知相关的大脑静息态网络的影响却知之甚少。本研究的目的是探讨轮班工作障碍（SWD）对静息态脑网络之间格兰杰因果关系连接的影响。
招募30例SWD患者和25例匹配的健康受试者，进行重复神经心理状态评估量表（RBANS）测试和静息态功能磁共振成像扫描。我们采用独立成分分析（ICA）提取静息态脑网络，并采用格兰杰因果分析（GCA）来表征与认知相关的静息态脑网络之间格兰杰因果关系连接的差异。
与健康受试者相比，SWD患者在注意力和即时记忆方面存在损害。识别出7个静息态脑网络，与健康受试者相比，SWD患者表现出更多的格兰杰因果关系连接。双样本检验结果显示，从前默认模式网络（aDMN）到感觉运动网络（SMN）以及从左额顶网络（LFPN）到突显网络（SN）的流入显著增加。相关性分析表明，从aDMN到SMN的流入增加与注意力得分呈负相关，而从LFPN到SN的流入与视觉空间/构建能力得分呈负相关。
本研究表明，SWD会损害认知表现，长期轮班工作后，SWD患者静息态网络之间特定的内在脑格兰杰因果连接受到影响。
