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具有潜在口腔外科应用的环丙沙星-胶原基材料。

Ciprofloxacin-Collagen-Based Materials with Potential Oral Surgical Applications.

作者信息

Ioan Daniel-Cristian, Rău Ileana, Albu Kaya Mădălina Georgiana, Radu Nicoleta, Bostan Marinela, Zgârian Roxana Gabriela, Tihan Graţiela Teodora, Dinu-Pîrvu Cristina-Elena, Lupuliasa Alina, Ghica Mihaela Violeta

机构信息

Department of General Chemistry, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, 1-7 Gh. Polizu Str., 011061 Bucharest, Romania.

Department of Collagen, National Research and Development Institute for Textile and Leather (INCDTP), Division Leather and Footwear Research Institute, 93 Ion Minulescu Str., 031215 Bucharest, Romania.

出版信息

Polymers (Basel). 2020 Aug 25;12(9):1915. doi: 10.3390/polym12091915.

DOI:10.3390/polym12091915
PMID:32854342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7563124/
Abstract

We report in this paper the synthesis and characterization of a new collagen-based material. This material was obtained in a spongy form and was functionalized with an antibiotic, ciprofloxacin. The targeted applications of these kind of materials concern the post-operative prophylaxis. The in vitro tests (antimicrobial, cytotoxic, drug release) showed that sponges with a concentration of 0.75 g of ciprofloxacin per gram of collagen could be beneficial for the desired applications.

摘要

我们在本文中报告了一种新型胶原基材料的合成与表征。该材料呈海绵状，并通过抗生素环丙沙星进行了功能化处理。这类材料的目标应用涉及术后预防。体外试验（抗菌、细胞毒性、药物释放）表明，每克胶原蛋白中含有0.75克环丙沙星的海绵可能对预期应用有益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d48/7563124/aeaa3dd26616/polymers-12-01915-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d48/7563124/1f455f406c23/polymers-12-01915-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d48/7563124/6cee9aa06d34/polymers-12-01915-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d48/7563124/8da390f024a3/polymers-12-01915-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d48/7563124/aeaa3dd26616/polymers-12-01915-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d48/7563124/1f455f406c23/polymers-12-01915-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d48/7563124/6cee9aa06d34/polymers-12-01915-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d48/7563124/8da390f024a3/polymers-12-01915-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d48/7563124/aeaa3dd26616/polymers-12-01915-g004.jpg

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Cisplatin effect on head and neck squamous cell carcinoma cells is modulated by ERK1/2 protein kinases.顺铂对头颈部鳞状细胞癌细胞的作用受ERK1/2蛋白激酶调控。
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Collagen-Based Tissue Engineering Strategies for Vascular Medicine.
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