Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, Mississippi.
Am J Physiol Regul Integr Comp Physiol. 2020 Oct 1;319(4):R476-R484. doi: 10.1152/ajpregu.00188.2020. Epub 2020 Sep 2.
Changes in cardiomyocyte metabolism have been heavily implicated in cardiac injury and heart failure (HF). However, there is emerging evidence that metabolism in nonmyocyte populations, including cardiac fibroblasts, immune cells, and endothelial cells, plays an important role in cardiac remodeling and adaptation to injury. Here, we discuss recent advances and insights into nonmyocyte metabolism in the healthy and injured heart. Metabolic switching from mitochondrial oxidative phosphorylation to glycolysis is critical for immune cell (macrophage and T lymphocyte) and fibroblast phenotypic switching in the inflamed and fibrotic heart. On the other hand, cardiac endothelial cells are heavily reliant on glycolytic metabolism, and thus impairments in glycolytic metabolism underlie endothelial cell dysfunction. Finally, we review current and ongoing metabolic therapies for HF and the potential implications for nonmyocyte metabolism.
心肌细胞代谢的变化与心脏损伤和心力衰竭（HF）密切相关。然而，越来越多的证据表明，非心肌细胞群（包括心脏成纤维细胞、免疫细胞和内皮细胞）的代谢在心脏重构和对损伤的适应中发挥着重要作用。在这里，我们讨论了健康和受损心脏中非心肌细胞代谢的最新进展和见解。代谢从线粒体氧化磷酸化向糖酵解的转变对于炎症和纤维化心脏中的免疫细胞（巨噬细胞和 T 淋巴细胞）和成纤维细胞表型的转变至关重要。另一方面，心脏内皮细胞严重依赖糖酵解代谢，因此糖酵解代谢受损是内皮细胞功能障碍的基础。最后，我们综述了 HF 的当前和正在进行的代谢治疗方法及其对非心肌细胞代谢的潜在影响。
