College of Food Science and Engineering, Jilin University, Changchun 130062, China.
College of Food Science and Engineering, Jilin University, Changchun 130062, China.
Food Chem. 2021 Mar 15;340:127933. doi: 10.1016/j.foodchem.2020.127933. Epub 2020 Aug 26.
Polysaccharides are the most abundant bioactive compounds in Ganoderma and have been widely used as dietary supplements in traditional Chinese medicine for thousands of years. Polysaccharides from Ganoderma exhibit unique biological properties, including anti-tumor, anti-inflammatory, and immunomodulatory activities. Herein, the sources and structures of polysaccharides from Ganoderma were presented. This work also reviews the immunomodulatory activities and possible mechanisms of polysaccharides from Ganoderma on different immune effector cells, including lymphocytes and myeloid cells. As an available adjunctive remedy, polysaccharides from Ganoderma can potentially be applied for the modulation of the host immune system, namely the innate immunity, the cellular immunity, and the humoral immunity.
多糖是灵芝中最丰富的生物活性化合物，几千年来一直被广泛用作中药的膳食补充剂。灵芝多糖具有独特的生物学特性，包括抗肿瘤、抗炎和免疫调节活性。本文介绍了灵芝多糖的来源和结构。还综述了灵芝多糖对不同免疫效应细胞（包括淋巴细胞和髓样细胞）的免疫调节活性及其可能的机制。作为一种有效的辅助治疗方法，灵芝多糖可能被应用于调节宿主免疫系统，即固有免疫、细胞免疫和体液免疫。
