Institute of Physics, Martin-Luther-University Halle-Wittenberg, 06099, Halle, Germany.
Institute of Medical Epidemiology, Biostatistics and Informatics, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, 06099, Halle, Germany.
Sci Rep. 2020 Sep 3;10(1):14530. doi: 10.1038/s41598-020-71539-0.
Respiratory rate and changes in respiratory activity provide important markers of health and fitness. Assessing the breathing signal without direct respiratory sensors can be very helpful in large cohort studies and for screening purposes. In this paper, we demonstrate that long-term nocturnal acceleration measurements from the wrist yield significantly better respiration proxies than four standard approaches of ECG (electrocardiogram) derived respiration. We validate our approach by comparison with flow-derived respiration as standard reference signal, studying the full-night data of 223 subjects in a clinical sleep laboratory. Specifically, we find that phase synchronization indices between respiration proxies and the flow signal are large for five suggested acceleration-derived proxies with [Formula: see text] for males and [Formula: see text] for females (means ± standard deviations), while ECG-derived proxies yield only [Formula: see text] for males and [Formula: see text] for females. Similarly, respiratory rates can be determined more precisely by wrist-worn acceleration devices compared with a derivation from the ECG. As limitation we must mention that acceleration-derived respiration proxies are only available during episodes of non-physical activity (especially during sleep).
呼吸频率和呼吸活动的变化提供了健康和健身的重要指标。在大型队列研究和筛查中，不使用直接呼吸传感器评估呼吸信号非常有帮助。在本文中，我们证明，腕部的长期夜间加速度测量比心电图（ECG）衍生的呼吸的四种标准方法能更好地提供呼吸代理。我们通过与流量衍生的呼吸作为标准参考信号进行比较来验证我们的方法，对临床睡眠实验室的 223 名受试者的全夜数据进行了研究。具体来说，我们发现，对于五个建议的加速度衍生代理中的五个代理，呼吸代理与流量信号之间的相位同步指数很大，男性为 [Formula: see text]，女性为 [Formula: see text]（平均值 ± 标准偏差），而 ECG 衍生的代理仅为男性提供 [Formula: see text]，女性为 [Formula: see text]。同样，与从 ECG 得出的结果相比，腕戴加速度设备可以更精确地确定呼吸率。作为限制，我们必须指出，加速度衍生的呼吸代理仅在非体力活动期间（尤其是在睡眠期间）可用。
