抗生素珠需要取出吗？
Do Antibiotic Beads Need to be Removed?
作者信息
Fernando Navin, Werner Shawn, Elhaddad Moamen, Davies Jonah, Firoozabadi Reza
机构信息
Hip and Knee Center at Northwest Primary and Specialty Care North Seattle, University of Washington, Seattle, WA, USA.
Aurora Medical Center Summit Oconomowoc, WI, USA.
出版信息
Arch Bone Jt Surg. 2020 Jul;8(4):502-505. doi: 10.22038/abjs.2020.44143.2208.
BACKGROUND
Polymethylmethacrylate antibiotic impregnated beads can be an effective treatment for chronic osteomyelitis or an adjuvant in the treatment of open fractures. It remains unclear however whether the beads cause long-term adverse events if not removed. The purpose of this study was to determine if removal of antibiotic beads was required in order to avoid long term complications.
METHODS
A retrospective chart review was conducted on patients with an extremity or pelvis fracture that had implantation of polymethylmethacrylate (PMMA) antibiotic beads over a five-year period.
RESULTS
Fifty-one patients met inclusion criteria for this study; thirty-seven patients (73%) did not have complications after surgical debridement and placement of PMMA antibiotic beads necessitating removal.
CONCLUSION
Our findings suggest that polymethylmethacrylate antibiotic beads can be utilized as a means of delivering high-dose concentrations of local antibiotics and do not have to be removed in all patients.
背景
聚甲基丙烯酸甲酯抗生素浸渍珠可有效治疗慢性骨髓炎或作为开放性骨折治疗的辅助手段。然而，如果不取出这些珠子，它们是否会导致长期不良事件仍不清楚。本研究的目的是确定是否需要取出抗生素珠以避免长期并发症。
方法
对在五年期间植入聚甲基丙烯酸甲酯（PMMA）抗生素珠的四肢或骨盆骨折患者进行回顾性病历审查。
结果
51例患者符合本研究的纳入标准；37例患者（73%）在手术清创和植入PMMA抗生素珠后未出现需要取出珠子的并发症。
结论
我们的研究结果表明，聚甲基丙烯酸甲酯抗生素珠可作为输送高剂量局部抗生素的一种手段，并非所有患者都必须取出。
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