Sherrill Samantha P, Timme Nicholas M, Beggs John M, Newman Ehren L
Department of Psychological and Brain Sciences and Program in Neuroscience, Indiana University Bloomington, Bloomington, IN, USA.
Department of Psychology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.
Netw Neurosci. 2020 Jul 1;4(3):678-697. doi: 10.1162/netn_a_00141. eCollection 2020.
Neural information processing is widely understood to depend on correlations in neuronal activity. However, whether correlation is favorable or not is contentious. Here, we sought to determine how correlated activity and information processing are related in cortical circuits. Using recordings of hundreds of spiking neurons in organotypic cultures of mouse neocortex, we asked whether mutual information between neurons that feed into a common third neuron increased synergistic information processing by the receiving neuron. We found that mutual information and synergistic processing were positively related at synaptic timescales (0.05-14 ms), where mutual information values were low. This effect was mediated by the increase in information transmission-of which synergistic processing is a component-that resulted as mutual information grew. However, at extrasynaptic windows (up to 3,000 ms), where mutual information values were high, the relationship between mutual information and synergistic processing became negative. In this regime, greater mutual information resulted in a disproportionate increase in redundancy relative to information transmission. These results indicate that the emergence of synergistic processing from correlated activity differs according to timescale and correlation regime. In a low-correlation regime, synergistic processing increases with greater correlation, and in a high-correlation regime, synergistic processing decreases with greater correlation.
人们普遍认为神经信息处理依赖于神经元活动的相关性。然而，相关性是否有利存在争议。在这里，我们试图确定在皮质回路中相关活动与信息处理是如何关联的。利用小鼠新皮质器官型培养物中数百个发放神经元的记录，我们研究了输入到同一个第三神经元的神经元之间的互信息是否会增加接收神经元的协同信息处理。我们发现，在互信息值较低的突触时间尺度（0.05 - 14毫秒）上，互信息与协同处理呈正相关。这种效应是由信息传输的增加介导的，协同处理是信息传输的一个组成部分，随着互信息的增加而产生。然而，在互信息值较高的突触外窗口（长达3000毫秒），互信息与协同处理之间的关系变为负相关。在这种情况下，更大的互信息导致相对于信息传输而言冗余度不成比例地增加。这些结果表明，相关活动产生的协同处理的出现根据时间尺度和相关状态而有所不同。在低相关状态下，协同处理随着相关性的增加而增加，而在高相关状态下，协同处理随着相关性的增加而减少。
