Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Rd, Nanshan District, Shenzhen, Guangdong, 518055, P. R. China.
GBA Research Innovation Institute for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, No. 11 Zhongguancun Beiyitiao, Beijing, 100190, P. R. China.
Angew Chem Int Ed Engl. 2020 Dec 21;59(52):23471-23475. doi: 10.1002/anie.202008584.
Adequately decorated gold nanoparticles (GNPs) have excellent antibiotic activities against multidrug-resistant (MDR) bacteria. Nanoparticles exhibiting Gram selective antibacterial actions are beneficial to precise therapy. Here, we present a strategy to tune the antibacterial spectrum of a small molecule (4,6-diamino-2-pyrimidinethiol, DAPT)-modified GNPs (DAPT-GNPs, DGNPs) by adjusting their sizes. Compared to large (ca. 14 nm diameter) DGNPs (lDGNPs) and medium-sized (3-4 nm diameter) DGNPs (mDGNPs), which have no antibacterial effect or only target Gram-negative (G-) bacteria, ultrasmall DGNPs (uDGNPs, <2 nm) have a broad antibacterial spectrum, especially showing an over 60-fold increase in antibacterial efficacy against Gram-positive (G+) bacteria. Moreover, the uDGNPs-functionalized scaffolds (agarose gel) can serve as general wound dressings for healing burnt infections. Our strategy is insightful for exploring properties of the nanomaterials and their applications.
经过适当修饰的金纳米颗粒（GNPs）对多药耐药（MDR）细菌具有优异的抗生素活性。表现出革兰氏选择性抗菌作用的纳米颗粒有利于精确治疗。在这里，我们提出了一种通过调整其尺寸来调节小分子（4,6-二氨基-2-嘧啶硫醇，DAPT）修饰的 GNPs（DAPT-GNPs，DGNPs）的抗菌谱的策略。与无抗菌作用或仅靶向革兰氏阴性（G-）细菌的大（约 14nm 直径）和中（3-4nm 直径）DGNPs（lDGNPs 和 mDGNPs）相比，超小 DGNPs（uDGNPs，<2nm）具有广谱抗菌活性，尤其是对革兰氏阳性（G+）细菌的抗菌效力提高了 60 多倍。此外，uDGNPs 功能化支架（琼脂糖凝胶）可用作治疗烧伤感染的一般伤口敷料。我们的策略为探索纳米材料的性质及其应用提供了新的思路。
