Research Center for Child Mental Development, Chiba University, Inohana, Chuo-ku, Chiba, 2608670, Japan.
Japan Society for the Promotion of Science, Tokyo, Japan.
BMC Psychiatry. 2020 Sep 4;20(1):433. doi: 10.1186/s12888-020-02841-4.
Cognitive behavioral therapy (CBT), which includes exposure and response prevention (ERP), is effective in improving symptoms of obsessive-compulsive disorder (OCD). However, whether poor cognitive functions and autism spectrum disorder (ASD) traits affect the therapeutic response of patients with OCD to ERP-based CBT remains unclear. This study aimed to identify factors predictive of the therapeutic response of Japanese patients with OCD to ERP-based CBT.
Forty-two Japanese outpatients with OCD were assessed using the Wechsler Adult Intelligence Scale-III (WAIS-III), Yale-Brown Obsessive-Compulsive Scale, Patient Health Questionnaire 9-item scale, and Autism Spectrum Quotient (AQ) at pre- and post-treatment. We used multiple regression analyses to estimate the effect on therapeutic response change. The treatment response change was set as a dependent variable in multiple regression analyses.
Multiple regression analyses showed that among independent variables, communication as an AQ sub-scale and Letter Number Sequencing as a WAIS-III sub-test predict the therapeutic response to ERP-based CBT .
Our results suggest that diminished working memory (Letter Number Sequencing), poor communication skill (AQ sub-scale) may undermine responsiveness to ERP-based CBT among patients with OCD.
UMIN, UMIN00024087 . Registered 20 September 2016 - Retrospectively registered (including retrospective data).
认知行为疗法（CBT），包括暴露和反应预防（ERP），可有效改善强迫症（OCD）的症状。然而，认知功能和自闭症谱系障碍（ASD）特征较差是否会影响强迫症患者对基于 ERP 的 CBT 的治疗反应尚不清楚。本研究旨在确定影响日本强迫症患者对基于 ERP 的 CBT 治疗反应的因素。
在治疗前后，使用韦氏成人智力量表第三版（WAIS-III）、耶鲁-布朗强迫症量表、患者健康问卷 9 项量表和自闭症谱系商数（AQ）评估了 42 名日本强迫症门诊患者。我们使用多元回归分析来估计对治疗反应变化的影响。将治疗反应变化设为多元回归分析中的因变量。
多元回归分析表明，在自变量中，作为 AQ 子量表的沟通和作为 WAIS-III 子测验的数字序列测验预测了基于 ERP 的 CBT 的治疗反应。
我们的结果表明，工作记忆（数字序列测验）下降和沟通技巧（AQ 子量表）较差可能会降低强迫症患者对基于 ERP 的 CBT 的反应性。
UMIN，UMIN00024087。注册于 2016 年 9 月 20 日-回顾性注册（包括回顾性数据）。
