儿童期起病的炎症性肠病中的癌症风险
Cancer Risk in Pediatric-Onset Inflammatory Bowel Disease.
作者信息
El-Matary Wael, Bernstein Charles N
机构信息
Department of Pediatrics, University of Manitoba, Winnipeg, MB, Canada.
Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada.
出版信息
Front Pediatr. 2020 Jul 17;8:400. doi: 10.3389/fped.2020.00400. eCollection 2020.
Abstract
Inflammatory bowel disease (IBD) is a chronic, immune-mediated, non-curable disease. The incidence of IBD appears to have risen over the last few decades especially in the pediatric age group. IBD usually presents with gastrointestinal symptoms, including abdominal pain, diarrhea, and bleeding per rectum but can also be associated with systemic symptoms such as weight loss, fatigue, joint and skin problems, and psychological comorbidities. One major complication is gastrointestinal and extra-intestinal malignancy. This review discusses literature that focuses on cancer risk of pediatric-onset IBD.
摘要
炎症性肠病（IBD）是一种慢性、免疫介导的不可治愈疾病。在过去几十年中，IBD的发病率似乎有所上升，尤其是在儿童年龄组。IBD通常表现为胃肠道症状，包括腹痛、腹泻和直肠出血，但也可能伴有全身症状，如体重减轻、疲劳、关节和皮肤问题以及心理合并症。一个主要并发症是胃肠道和肠外恶性肿瘤。本综述讨论了关注儿童期发病IBD癌症风险的文献。
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