Li Qing, Yu Honggang
Department of Gastroenterology, Renmin Hospital of Wuhan University Wuhan 430060, Hubei, P. R. China.
Hubei Key Laboratory of Digestive System, Renmin Hospital of Wuhan University Wuhan 430060, Hubei, P. R. China.
Am J Cancer Res. 2020 Aug 1;10(8):2271-2281. eCollection 2020.
There is a complex ecosystem of bacteria and other microorganisms inside and outside the human body, which play an intricate role in maintaining health. In recent years, many researches focused on the relationship between microorganisms and cancer. Studies have identified that numerous microbes are presented in human stomach, which are closely linked to the development of gastric cancer (GC). is the mostly well-studied bacterial pathogen in the stomach, which account for the vast majority of GC. However, recent studies have found that microflora dysbiosis was occurred in mucosa of GC patients, and evidences have potentially proved that microbes other than are also contribute to the development of GC, while the overall knowledge is still limited. In this review, we summarized the role of gastric flora in GC, especially the possible role of non- bacteria in the development of GC. These knowledges and awareness may open doors for new therapeutic strategies of GC.
人体内外存在着一个由细菌和其他微生物组成的复杂生态系统，它们在维持健康方面发挥着错综复杂的作用。近年来，许多研究聚焦于微生物与癌症之间的关系。研究已证实，人类胃部存在大量微生物，它们与胃癌（GC）的发生密切相关。幽门螺杆菌是胃部研究最为充分的细菌病原体，在大多数胃癌病例中都有它的身影。然而，最近的研究发现，胃癌患者的黏膜中出现了微生物群落失调，有证据初步证明，除幽门螺杆菌之外的微生物也会促使胃癌的发生，不过总体认识仍较为有限。在这篇综述中，我们总结了胃内菌群在胃癌中的作用，尤其是非幽门螺杆菌细菌在胃癌发生过程中可能发挥的作用。这些认识或许会为胃癌的新治疗策略开辟道路。
